International audienceWe studied Rag2-deficient mice bearing two rearranged alphabeta TCR transgenes, both restricted to the MHC H-2D(b) class I molecule. We have previously shown that, in these DTg mice, most peripheral CD8 T cells express one TCRbeta chain associated with two TCRalpha chains, as in one-third of the mature T cells from normal mice. We examined the functional behavior of the dual-receptor CD8 T cells developing either in the absence or in the presence of self-Ag. The dual-receptor CD8 T cells, which develop in absence of self-Ag, show efficient responses to immunization and remain sensitive to induction of peripheral tolerance. In contrast to single TCR T cells, the dual-TCR cells, when tolerized upon exposure to high level...
T cell receptor transgenic mice have had an increasingly large impact on immunological research for ...
The immunomodulatory properties of CD8 T cells with regulatory phenotype have become evident. It rem...
SummaryCD8+ T cell tolerance, although essential for preventing autoimmunity, poses substantial obst...
International audienceWe derived Rag2-deficient mice bearing two rearranged alphabeta TCR transgenes...
International audienceThe presence of B cells expressing two B cell receptors (BCR), described in BC...
Within the T cell system, self-tolerance is mainly maintained by thymic clonal deletion of self-reac...
CD8+ T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to generatin...
To be effective in recognizing a wide variety of pathogens, the adaptive immune system must generate...
T cells that express 2 T cell receptors (TCRs), generated by productive rearrangement of both TCRα l...
International audienceIn this investigation we compare the repopulation of the CD8+ T cell compartme...
Amongst CD4-CD8- (double negative) thymocytes there is a sizeable population (variable from strain t...
Regulatory mechanisms of T cell autoreactivity to MHC class II molecules were studied in transgenic ...
Recombination activating gene (RAG)-deficient TCR (T Cell Receptor) Tg (transgenic) mice are routine...
Central tolerance to tumor-associated Ags is an immune-escape mechanism that significantly limits th...
AbstractUnder most circumstances, allelic exclusion at the T cell receptor (TCR)β locus is tightly r...
T cell receptor transgenic mice have had an increasingly large impact on immunological research for ...
The immunomodulatory properties of CD8 T cells with regulatory phenotype have become evident. It rem...
SummaryCD8+ T cell tolerance, although essential for preventing autoimmunity, poses substantial obst...
International audienceWe derived Rag2-deficient mice bearing two rearranged alphabeta TCR transgenes...
International audienceThe presence of B cells expressing two B cell receptors (BCR), described in BC...
Within the T cell system, self-tolerance is mainly maintained by thymic clonal deletion of self-reac...
CD8+ T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to generatin...
To be effective in recognizing a wide variety of pathogens, the adaptive immune system must generate...
T cells that express 2 T cell receptors (TCRs), generated by productive rearrangement of both TCRα l...
International audienceIn this investigation we compare the repopulation of the CD8+ T cell compartme...
Amongst CD4-CD8- (double negative) thymocytes there is a sizeable population (variable from strain t...
Regulatory mechanisms of T cell autoreactivity to MHC class II molecules were studied in transgenic ...
Recombination activating gene (RAG)-deficient TCR (T Cell Receptor) Tg (transgenic) mice are routine...
Central tolerance to tumor-associated Ags is an immune-escape mechanism that significantly limits th...
AbstractUnder most circumstances, allelic exclusion at the T cell receptor (TCR)β locus is tightly r...
T cell receptor transgenic mice have had an increasingly large impact on immunological research for ...
The immunomodulatory properties of CD8 T cells with regulatory phenotype have become evident. It rem...
SummaryCD8+ T cell tolerance, although essential for preventing autoimmunity, poses substantial obst...