The Use of High Electric Pluse for Biomedical Sensing

[[abstract]]本論文研究，主要是利用直流升壓型轉換器(DC-DC Boost Converter)方式產生100V、200V、400V電壓，搭配脈波寬度調變技術(Pluse Width Wodulation,PWM)產生脈波寬度1ms與2ms之脈波，和遲滯電壓比較器，驅動升壓型轉換器之切換開關進行電壓輸出，再與生物檢測器結合，對皮膚進行電穿孔實驗測試，對皮膚組織進行電穿孔實驗，當皮膚組織中的脂質雙層細胞因高電壓產生微小孔洞時，利用滲透法靜置將尿素抽取出來。 依據論文實驗數據結果可知，實驗中所搭配利用的升壓型直流脈波高壓電源供應器，對應用於皮膚電穿孔有一定之效果，未來整合出一套系統儀器後對經皮投藥或者是蛋白質、基因的抽取都可利用此法靈活運用，而許多慢性病患者例如:洗腎患者，亦可利用此技術居家自我檢測尿素變化，一達洗腎需求時即可前往洗腎，而非固定時間才去洗腎，可使患者健康及生活品質更提升。[[abstract]]The principal aim of this study was to use a DC-DC boost converter to produce voltages of 100, 200, and 400V in combination with pulse width modulation (PWM) technology to produce pulse waves with widths of 1 or 2ms and voltage comparator. Voltage output was performed using the change-over switch of the DC-DC boost converter in combination with a bioscanner to perform a skin electroporation test using high voltage. A small hole was opened in the lipid bilayer of cells in skin tissue, which was then used for stationary extraction of urea through osmosis. The test results from this study showed that the DC-DC boost converter pulse power supply unit used in this experiment was effective while used in skin electroporation. After making system adjustments, future possible applications included transdermal injection and extraction of proteins and genes. This technology can be possibly used in patients with chronic diseases, such as dialysis patients. This technology can also be used for self-examination of urea changing at home. This will allow renal dialysis to be performed at non-fixed times as needed, which can improve the health and quality of life of patients.[[note]]碩