Driving circuit design for the reverse iontophoresis and electroporation on the application of non-invasive sensing system for multi-metabolites

[[abstract]]血液的取樣是主要的診斷與偵測對於疾病，但非常的不方便、痛苦等等，因此開發一個非侵入多重生理感測系統是非常重要，因為糖尿病與痛風在台灣是個嚴重的問題，這個研究重點在於糖尿病與痛風所對應的相關生理代謝物(葡萄糖、尿酸)。 研究目的(1)設計一個低成本、可攜帶、電池驅動及可程式的電穿孔與反離子透入法之驅動電路應用於經皮層抽取多重生理代謝物 (2)找出一個最佳化的電穿孔與反離子透入法的組合對於經皮層抽取葡萄糖與尿酸。 結果顯示準確、可攜帶、可程式、低成本的電穿孔與反離子透入法之驅動電路，應用於葡萄糖與尿酸之經皮層抽取之評估穿過豬皮在滲透器上。 結論，一個低成本、可攜帶、電池驅動、可程式的電穿孔與反離子透入法電路被設計出來並且可能有效的應用於經皮層抽取之葡萄糖與尿酸。[[abstract]]Blood sampling is the most common approach for disease diagnosis and monitoring but it is inconvenient, painful and etc. Therefore, development of non-invasive multi-metabolites sensing system is very important. Because diabetes and gout are a serious problem in Taiwan, this study focused on the related metabolites (i.e. glucose and uric acid) corresponding to these two diseases. The aims of this study were (1) to design and fabricate a circuit of low-cost, portable, battery-operation and programmable electroporation and reverse iontophoresis device for multi-metabolites transdermal extraction and (2) to find out the optimum combination of electroporation and reverse iontophoresis for the non-invasive and transdermal extraction of glucose and uric acid. Results showed that the reverse iontophoresis and electroporation device was accurate. Moreover, the device was portable, programmable and low-cost. Furthermore, the device was capable of extracting glucose and uric acid transdermally and this was evaluation by the use of diffusion cell incorporated with porcine skin. In conclusion, a low-cost, portable, battery-operation and programmable electroporation and reverse iontophoresis device was developed in this study and it was able to effectively and transdermally extract glucose and uric acid.[[note]]碩