In cells, peptides and proteins are sometimes prone to aggregation. In neurons, for example, amyloid beta peptides form plaques related to Alzheimer's disease (AD). The corresponding kinetic models either ignore or do not pay attention to degradation of these species. Here, the author proposes a generic kinetic model describing formation and degradation of linear aggregates. The process is assumed to occur via reversible association of monomers and attachment of monomers to or detachment from terminal parts of aggregates. Degradation of monomers is described as a first-order process. Degradation of aggregates is considered to occur at their terminal and internal parts with different rates and these steps are described by first-order equatio...
This work describes the development and application of computational models for the investigation of...
The paper presents a conceptual mathematical model for Alzheimer's disease (AD). According to the so...
More than twenty types of proteins can adopt misfolded conforma-tions, which can co-aggregate into a...
In cells, peptides and proteins are sometimes prone to aggregation. In neurons, for example, amyloid...
The deposition of pathological protein aggregates in the brain plays a central role in cognitive dec...
International audienceProtein polymerization consists in the aggregation of single monomers into pol...
Protein polymerization consists in the aggregation of single monomers into polymers that may fragmen...
<div><p>Protein polymerization consists in the aggregation of single monomers into polymers that may...
Protein misfolding and concomitant aggregation towards amyloid formation is the underlying biochemic...
The formation of aggregates from a range of normally soluble peptides and proteins is the hallmark o...
Dementia associated with the Alzheimer's disease is thought to be correlated with the conversion of ...
AbstractSpontaneous conversion of beta-amyloid peptide (Aβ) from soluble monomer to insoluble fibril...
The formation of amyloid fibrils from soluble peptide is a hallmark of many neurodegenerative diseas...
Protein misfolding and concomitant aggregation towards amyloid formation is the underlying biochemic...
Proteinmisfolding and self-assembly into variousmorphologicaggregates are widespread phenomena in th...
This work describes the development and application of computational models for the investigation of...
The paper presents a conceptual mathematical model for Alzheimer's disease (AD). According to the so...
More than twenty types of proteins can adopt misfolded conforma-tions, which can co-aggregate into a...
In cells, peptides and proteins are sometimes prone to aggregation. In neurons, for example, amyloid...
The deposition of pathological protein aggregates in the brain plays a central role in cognitive dec...
International audienceProtein polymerization consists in the aggregation of single monomers into pol...
Protein polymerization consists in the aggregation of single monomers into polymers that may fragmen...
<div><p>Protein polymerization consists in the aggregation of single monomers into polymers that may...
Protein misfolding and concomitant aggregation towards amyloid formation is the underlying biochemic...
The formation of aggregates from a range of normally soluble peptides and proteins is the hallmark o...
Dementia associated with the Alzheimer's disease is thought to be correlated with the conversion of ...
AbstractSpontaneous conversion of beta-amyloid peptide (Aβ) from soluble monomer to insoluble fibril...
The formation of amyloid fibrils from soluble peptide is a hallmark of many neurodegenerative diseas...
Protein misfolding and concomitant aggregation towards amyloid formation is the underlying biochemic...
Proteinmisfolding and self-assembly into variousmorphologicaggregates are widespread phenomena in th...
This work describes the development and application of computational models for the investigation of...
The paper presents a conceptual mathematical model for Alzheimer's disease (AD). According to the so...
More than twenty types of proteins can adopt misfolded conforma-tions, which can co-aggregate into a...