Add to ORKGAbnormalities in cellular functions are associated with the progression of human diseases, often resulting in metabolic reprogramming. GEnome-scale metabolic Models (GEMs) have enabled studying global metabolic reprogramming in connection with disease development in a systematic manner. Here we review recent work on reconstruction of GEMs for human cell/tissue types and cancer, and the use of GEMs for identification of metabolic changes occurring in response to disease development. We further discuss how GEMs can be used for the development of efficient therapeutic strategies. Finally, challenges in integration of cell/tissue models for simulation of whole body functions as well as integration of GEMs with other biological networks for gene...
The growing prevalence of metabolic diseases, such as obesity and diabetes, are putting a high strai...
Abstract Background Genome-scale metabolic reconstructions provide a biologically meaningful mechani...
Altered metabolism has long been recognized as a defining property of cancer physiology, but is expe...
Abnormalities in cellular functions are associated with the progression of human diseases, often res...
The arising prevalence of metabolic diseases calls for a holistic approach for analysis of the under...
Advances in genome sequencing, high throughput measurement of gene and protein expression levels, da...
Altered metabolism is linked to the appearance of various human diseases and a better understanding ...
Metabolic rewiring or reprogramming is the alteration of metabolism in living organisms, leading to ...
Cancer cells reprogram metabolism to support rapid proliferation and survival. Energy metabolism is ...
Genome-scale metabolic models (GEMs) are mathematical models that enable systematic analysis of meta...
In the last years, the analysis of cellular metabolism has sparked new interest in systems biology a...
Metabolism is the process by which cells and organisms obtain nutrients and energy to perform their ...
Cancer is a leading cause of death in the world, and the mechanisms underlying this disease are stil...
Altered metabolism is associated with many human diseases. Human genome-scale metabolic models (GEMs...
Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold f...
The growing prevalence of metabolic diseases, such as obesity and diabetes, are putting a high strai...
Abstract Background Genome-scale metabolic reconstructions provide a biologically meaningful mechani...
Altered metabolism has long been recognized as a defining property of cancer physiology, but is expe...
Abnormalities in cellular functions are associated with the progression of human diseases, often res...
The arising prevalence of metabolic diseases calls for a holistic approach for analysis of the under...
Advances in genome sequencing, high throughput measurement of gene and protein expression levels, da...
Altered metabolism is linked to the appearance of various human diseases and a better understanding ...
Metabolic rewiring or reprogramming is the alteration of metabolism in living organisms, leading to ...
Cancer cells reprogram metabolism to support rapid proliferation and survival. Energy metabolism is ...
Genome-scale metabolic models (GEMs) are mathematical models that enable systematic analysis of meta...
In the last years, the analysis of cellular metabolism has sparked new interest in systems biology a...
Metabolism is the process by which cells and organisms obtain nutrients and energy to perform their ...
Cancer is a leading cause of death in the world, and the mechanisms underlying this disease are stil...
Altered metabolism is associated with many human diseases. Human genome-scale metabolic models (GEMs...
Genome-scale metabolic models (GEMs) are valuable tools to study metabolism and provide a scaffold f...
The growing prevalence of metabolic diseases, such as obesity and diabetes, are putting a high strai...
Abstract Background Genome-scale metabolic reconstructions provide a biologically meaningful mechani...
Altered metabolism has long been recognized as a defining property of cancer physiology, but is expe...