Add to ORKGIn embryonic stem cells, removal of oxidatively damaged proteins is triggered upon the first signs of cell fate specification but the underlying mechanism is not known. Here, we report that this phase of differentiation encompasses an unexpected induction of genes encoding the proteasome activator PA28 alpha beta (11S), subunits of the immunoproteasome (20Si), and the 20Si regulator TNF alpha. This induction is accompanied by assembly of mature PA28-20S(i) proteasomes and elevated proteasome activity. Inhibiting accumulation of PA28 alpha using miRNA counteracted the removal of damaged proteins demonstrating that PA28 alpha beta has a hitherto unidentified role required for resetting the levels of protein damage at the transition from self-...
Summary: Adult muscle stem cells (satellite cells) are required for adult skeletal muscle regenerati...
The proteasome is essential for the selective degradation of most cellular proteins. To survive over...
Doctor of PhilosophyDivision of BiologyJeroen RoelofsProteasomes are molecular complexes that degrad...
In embryonic stem cells, removal of oxidatively damaged proteins is triggered upon the first signs o...
During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromole...
International audienceDuring mammalian aging, cellular proteins become increasingly damaged: for exa...
2012-05-02Oxidized cytoplasmic and nuclear proteins are normally degraded by the proteasome, but acc...
SummaryThe ability of stem cells to activate different gene expression programs requires the choreog...
Human embryonic stem cells (hESCs) exhibit high levels of proteasome activity, an intrinsic characte...
Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for cell...
Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome function is vuln...
A new report (Szutorisz et al., 2006) suggests that embryonic stem (ES) cells adopt an unusual strat...
Maintaining protein homeostasis is vital to cell viability, with numerous studies demonstrating a ro...
Histone proteolysis is a poorly understood phenomenon in which the N-terminal tails of histones are ...
Nuclear factor, erythroid 2-like 2 (Nrf2) is a master transcription factor for cellular defense agai...
Summary: Adult muscle stem cells (satellite cells) are required for adult skeletal muscle regenerati...
The proteasome is essential for the selective degradation of most cellular proteins. To survive over...
Doctor of PhilosophyDivision of BiologyJeroen RoelofsProteasomes are molecular complexes that degrad...
In embryonic stem cells, removal of oxidatively damaged proteins is triggered upon the first signs o...
During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromole...
International audienceDuring mammalian aging, cellular proteins become increasingly damaged: for exa...
2012-05-02Oxidized cytoplasmic and nuclear proteins are normally degraded by the proteasome, but acc...
SummaryThe ability of stem cells to activate different gene expression programs requires the choreog...
Human embryonic stem cells (hESCs) exhibit high levels of proteasome activity, an intrinsic characte...
Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for cell...
Proteasomes are central regulators of protein homeostasis in eukaryotes. Proteasome function is vuln...
A new report (Szutorisz et al., 2006) suggests that embryonic stem (ES) cells adopt an unusual strat...
Maintaining protein homeostasis is vital to cell viability, with numerous studies demonstrating a ro...
Histone proteolysis is a poorly understood phenomenon in which the N-terminal tails of histones are ...
Nuclear factor, erythroid 2-like 2 (Nrf2) is a master transcription factor for cellular defense agai...
Summary: Adult muscle stem cells (satellite cells) are required for adult skeletal muscle regenerati...
The proteasome is essential for the selective degradation of most cellular proteins. To survive over...
Doctor of PhilosophyDivision of BiologyJeroen RoelofsProteasomes are molecular complexes that degrad...