Recently, a defect in pertussis toxin-independent actions of epinephrine on pancreatic B-cells of fa/fa Zucker rats was reported (Cawthorn and Chan (1991) Mol. Cell. Endocrinol. 75, 197-204). We now report studies of islet alpha 2-adrenoceptor function of fa/fa rats. Insulin and cAMP production by islets of obese rats were both inhibited by the alpha 2-adrenoceptor agonist clonidine. Calculated pD2 values for clonidine were 9.57 +/- 0.59 and 9.43 +/- 0.33 for lean and fa/fa rat islets, respectively. Yohimbine reversed clonidine effects equipotently in lean and obese rat islets (pA2 values of 7.48 +/- 0.57 vs 7.43 +/- 0.58). Unexpectedly, the alpha 1-antagonist prazosin stimulated insulin secretion from islets of obese but not lean rats. Fun...
Although the a- and /3-adrenergic receptors have opposing effects on insulin secretion, the inhibito...
Effects of the alpha 2-adrenergic agonist clonidine on insulin release, membrane potential, and cyto...
Rat islets were used to compare the mechanisms whereby adenosine and adrenaline inhibit insulin rele...
Using isolated pancreatic islets from adult, weanling and suckling rats, the time of onset of functi...
Adult obese (fa/fa) Zucker rats hypersecrete insulin in response to glucose and other secretagogues....
AbstractThe rate of glucose utilization in isolated pancreatic islets of the rat was inhibited by th...
The obese (fa/fa) Zucker rat is a genetic model of childhood-onset obesity in humans. Pathological c...
The selective α1-adrenergic agonist amidephrine mesylate, when used at concentrations ranging from 0...
Adrenalectomy prevents development of obesity and hyperinsulinaemia in obese (fa/fa) Zucker rats, th...
SIGLEAvailable from British Library Document Supply Centre- DSC:DX95711 / BLDSC - British Library Do...
Conflicting opinions were recently expressed concerning the possible effect of α2-adrenergic agonist...
In the present study, the changes in the brain EPI (Epinephrine), adrenergic receptors and the recep...
Young adult obese fa/fa Zucker rats are hyperinsulinemic, hyperlipidemic and insulin resistant. Panc...
The hypothesis that a defect in glucose sensing by islets of fa/fa Zucker rats contributes to hyperi...
Chronic adrenergic stimulation is the dominant factor in impairment of the β-cell function. Sustaine...
Although the a- and /3-adrenergic receptors have opposing effects on insulin secretion, the inhibito...
Effects of the alpha 2-adrenergic agonist clonidine on insulin release, membrane potential, and cyto...
Rat islets were used to compare the mechanisms whereby adenosine and adrenaline inhibit insulin rele...
Using isolated pancreatic islets from adult, weanling and suckling rats, the time of onset of functi...
Adult obese (fa/fa) Zucker rats hypersecrete insulin in response to glucose and other secretagogues....
AbstractThe rate of glucose utilization in isolated pancreatic islets of the rat was inhibited by th...
The obese (fa/fa) Zucker rat is a genetic model of childhood-onset obesity in humans. Pathological c...
The selective α1-adrenergic agonist amidephrine mesylate, when used at concentrations ranging from 0...
Adrenalectomy prevents development of obesity and hyperinsulinaemia in obese (fa/fa) Zucker rats, th...
SIGLEAvailable from British Library Document Supply Centre- DSC:DX95711 / BLDSC - British Library Do...
Conflicting opinions were recently expressed concerning the possible effect of α2-adrenergic agonist...
In the present study, the changes in the brain EPI (Epinephrine), adrenergic receptors and the recep...
Young adult obese fa/fa Zucker rats are hyperinsulinemic, hyperlipidemic and insulin resistant. Panc...
The hypothesis that a defect in glucose sensing by islets of fa/fa Zucker rats contributes to hyperi...
Chronic adrenergic stimulation is the dominant factor in impairment of the β-cell function. Sustaine...
Although the a- and /3-adrenergic receptors have opposing effects on insulin secretion, the inhibito...
Effects of the alpha 2-adrenergic agonist clonidine on insulin release, membrane potential, and cyto...
Rat islets were used to compare the mechanisms whereby adenosine and adrenaline inhibit insulin rele...