APPLICATION OF GAS CHROMATOGRAPHY-SURFACE IONIZATION DETECTION TO FORENSIC TOXICOLOGY

Tricyclic antidepressants and local anesthetics were detected by gas chromatography (GC)-surface ionization detection (SID), which has been reported to be very sensitive and specific to tertiary amines. The detection limit in an injected volume was 5-10 pg for amitriptyline, imipramine, trimipramine, chlorimipramine, lidocaine, mepivacaine and bupivacaine, and 100-200 pg for procaine, benoxinate and dibucaine. When compared with the GC-nitrogen-phosphorus detection (NPD), the GC-SID sensitivity was 10-100 times higher, the background was cleaner, and the baseline remained steady as the column temperature was increased. The drugs could bee rapidly isolated with Sep-Pak C18 cartridges from biological fluids before GC. The recovery of the drugs was more than 60%.rights:日本法中毒学会rights:本文データは日本法中毒学会の許諾のもと掲載しています