Generation of powerful and highly specific immune responses against invading pathogens is essential to our survival. However, the immune system can cause disease if activated in an inappropriate manner. Examples include production of IgE antibodies against harmless environmental antigens in allergy and production of IgG antibodies against self-antigens in autoimmunity. Thus, as the antibody-producing cells of the immune system, B cells play a key role in the pathology of both allergic and autoimmune disease. The aim of the work presented in this thesis was to investigate how B cell activation is regulated by components of the innate immune system in allergy and autoimmunity. In papers I and II, regulation of autoreactive and IgE-pr...
In mice, B1 and marginal zone (MZ) B-cells play an important role in prevention of autoimmunity thro...
B lymphocytes are a type of white blood cells, belonging to the adaptive arm of the immune system an...
Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. Th...
The immune system needs to be efficient to protect organisms from invading pathogens. Lymphoid orga...
The immune system protects individuals against infections but can cause disease if the response is u...
Our immune system protects us from invading pathogens such as bacteria, viruses, fungi and parasite...
A diverse repertoire of B cell specificities is critical to combat pathogenic threats, but this dive...
URPOSE OF REVIEW: The establishment of long-term clinical tolerance in AIT requires the involveme...
B lymphocytes are a major player in the immune system and their best understood effector functions a...
B cells are essential for the development and pathogenesis of both systemic and organ-specific autoi...
AbstractThe pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanis...
Invariant natural killer T (NKT) cells are innate-like lymphocytes with both immunoregulatory and cy...
B cells are critical for the generation of antibody, but there is increasing evidence that they hav...
In allergic disease, IgE is the antibody which can bind to non-pathogenic allergens such as pollens,...
Immune activation comprises multiple biological checkpoints to ensure proper and regulated effector...
In mice, B1 and marginal zone (MZ) B-cells play an important role in prevention of autoimmunity thro...
B lymphocytes are a type of white blood cells, belonging to the adaptive arm of the immune system an...
Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. Th...
The immune system needs to be efficient to protect organisms from invading pathogens. Lymphoid orga...
The immune system protects individuals against infections but can cause disease if the response is u...
Our immune system protects us from invading pathogens such as bacteria, viruses, fungi and parasite...
A diverse repertoire of B cell specificities is critical to combat pathogenic threats, but this dive...
URPOSE OF REVIEW: The establishment of long-term clinical tolerance in AIT requires the involveme...
B lymphocytes are a major player in the immune system and their best understood effector functions a...
B cells are essential for the development and pathogenesis of both systemic and organ-specific autoi...
AbstractThe pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanis...
Invariant natural killer T (NKT) cells are innate-like lymphocytes with both immunoregulatory and cy...
B cells are critical for the generation of antibody, but there is increasing evidence that they hav...
In allergic disease, IgE is the antibody which can bind to non-pathogenic allergens such as pollens,...
Immune activation comprises multiple biological checkpoints to ensure proper and regulated effector...
In mice, B1 and marginal zone (MZ) B-cells play an important role in prevention of autoimmunity thro...
B lymphocytes are a type of white blood cells, belonging to the adaptive arm of the immune system an...
Natural killer T cells (NKT) are a subset of T lymphocytes bridging innate and adaptive immunity. Th...