Regulated gene expression is widely useful for gene function studies and as a means to control genes important in disease. There are many methods for regulating the expression of genes, and one approach is to use antisense oligonucleotides that bind complementary mRNAs to inhibit translation. A number of nucleic acid analogues and mimics have been developed to improve antisense efficiency. Peptide nucleic acid (PNA) is a DNA mimic with many interesting properties. PNA has proven effective in a variety of applications and mRNA has been a frequent target with the aim to silence gene expression in a sequence specific manner. However, mRNA targeting antisense PNA has almost exclusively been used on eukaryotic cells and relatively little ...
Antisense RNA molecules in bacteria cause inhibition of translation of specific mRNA molecules and r...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
AbstractThe recognition of cellular nucleic acids by synthetic oligonucleotides is a versatile strat...
Regulated gene expression is widely useful for gene function studies and as a means to control gene...
There is a need for new antibacterial agents, and one attractive strategy is to develop nucleic acid...
ii Nucleic acids and proteins are abundant linear biopolymers in living organisms. Much of my resear...
Nowadays antibiotics are overused in human treatment, agriculture and animal breading. Bacteria can ...
Abstract An important objective in developing new drugs is the achievement of high specificity to ma...
Antibiotics have formed a corner stone of modern medicine. However, bacteria can develop resistance ...
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glyc...
Broad-spectrum antimicrobials kill indiscriminately, a property that can lead to negative clinical c...
The use of PNAs in therapeutics is limited by its mechanism of action. PNA (peptide nucleic acid) ac...
Klebsiella pneumoniae causes common and severe hospital- and community-acquired infections with a hi...
PhD ThesisThe emergence of multiple-antibiotic resistance among clinical pathogens has created an ur...
Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine pe...
Antisense RNA molecules in bacteria cause inhibition of translation of specific mRNA molecules and r...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
AbstractThe recognition of cellular nucleic acids by synthetic oligonucleotides is a versatile strat...
Regulated gene expression is widely useful for gene function studies and as a means to control gene...
There is a need for new antibacterial agents, and one attractive strategy is to develop nucleic acid...
ii Nucleic acids and proteins are abundant linear biopolymers in living organisms. Much of my resear...
Nowadays antibiotics are overused in human treatment, agriculture and animal breading. Bacteria can ...
Abstract An important objective in developing new drugs is the achievement of high specificity to ma...
Antibiotics have formed a corner stone of modern medicine. However, bacteria can develop resistance ...
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glyc...
Broad-spectrum antimicrobials kill indiscriminately, a property that can lead to negative clinical c...
The use of PNAs in therapeutics is limited by its mechanism of action. PNA (peptide nucleic acid) ac...
Klebsiella pneumoniae causes common and severe hospital- and community-acquired infections with a hi...
PhD ThesisThe emergence of multiple-antibiotic resistance among clinical pathogens has created an ur...
Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine pe...
Antisense RNA molecules in bacteria cause inhibition of translation of specific mRNA molecules and r...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
AbstractThe recognition of cellular nucleic acids by synthetic oligonucleotides is a versatile strat...