Add to ORKGUnrestrictedLymphoid-specific protein tyrosine phosphatase (LYP) has been found to be one of the most potent inhibitors of T cell subpopulation activation. A gain-of-function single nucleotide polymorphism (SNP) C1858T has been shown to be involved in several autoimmune diseases. We compared the enzymatic activity of LYP and Pro, Glu, Ser, Thr-rich protein tyrosine phosphatase (PEST). In vitro biochemical studies showed that LYP could differentially hydrolyze several phosphatase substrates. We screened a small molecule library for potential LYP inhibitors. In addition, our siRNA studies confirmed that T-cell receptor signaling was enhanced once LYP expression got repressed
A gain-of-function R620W polymorphism in the PTPN22 gene, encoding the lymphoid tyrosine phosphatase...
Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signa...
A gain-of-function R620W polymorphism in the PTPN22 gene, encoding the lymphoid tyrosine phosphatase...
UnrestrictedPTPs involved in modulation of signal transduction through the T cell receptor (TCR) are...
The Lymphoid specific tyrosine phosphatase (Lyp) has elicited tremendous research interest due to th...
Lymphoid-specific tyrosine phosphatase (Lyp), a critical signaling regulator of immune cells, is ass...
Restricted until 07 May. 2012.Protein tyrosine kinases and protein tyrosine phosphatases maintain a ...
The Lymphoid specific tyrosine phosphatase (Lyp) has elicited tremendous research interest due to th...
The PTPN22 gene encoding the Lyp/Pep protein tyrosine phosphatase has recently been described as a n...
A missense C1858T single nucleotide polymorphism in the PTPN22 gene recently emerged as a major risk...
A missense C1858T single nucleotide polymorphism in the PTPN22 gene recently emerged as a major risk...
Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signa...
Producción CientíficaThe protein tyrosine phosphatase LYP, a key regulator of TCR signaling, present...
The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide...
A C1858T (R620W) variation in the PTPN22 gene encoding the tyrosine phosphatase LYP is a major risk ...
A gain-of-function R620W polymorphism in the PTPN22 gene, encoding the lymphoid tyrosine phosphatase...
Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signa...
A gain-of-function R620W polymorphism in the PTPN22 gene, encoding the lymphoid tyrosine phosphatase...
UnrestrictedPTPs involved in modulation of signal transduction through the T cell receptor (TCR) are...
The Lymphoid specific tyrosine phosphatase (Lyp) has elicited tremendous research interest due to th...
Lymphoid-specific tyrosine phosphatase (Lyp), a critical signaling regulator of immune cells, is ass...
Restricted until 07 May. 2012.Protein tyrosine kinases and protein tyrosine phosphatases maintain a ...
The Lymphoid specific tyrosine phosphatase (Lyp) has elicited tremendous research interest due to th...
The PTPN22 gene encoding the Lyp/Pep protein tyrosine phosphatase has recently been described as a n...
A missense C1858T single nucleotide polymorphism in the PTPN22 gene recently emerged as a major risk...
A missense C1858T single nucleotide polymorphism in the PTPN22 gene recently emerged as a major risk...
Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signa...
Producción CientíficaThe protein tyrosine phosphatase LYP, a key regulator of TCR signaling, present...
The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide...
A C1858T (R620W) variation in the PTPN22 gene encoding the tyrosine phosphatase LYP is a major risk ...
A gain-of-function R620W polymorphism in the PTPN22 gene, encoding the lymphoid tyrosine phosphatase...
Lymphoid tyrosine phosphatase (LYP) and C-terminal Src kinase (CSK) are negative regulators of signa...
A gain-of-function R620W polymorphism in the PTPN22 gene, encoding the lymphoid tyrosine phosphatase...