Add to ORKGUnrestrictedThe timing of natural menopause is an important breast cancer risk factor. Several epidemiological studies suggest that the timing of natural menopause has a strong genetic component. We used existing genotype data from BPC3 to investigate the association between common genetic variation in the form of SNPs in three candidate genes (GNRH1, GNRHR, FSHB) and the timing of natural menopause. For FSHB, subjects carrying the heterozygous (CT) genotype (OR, 1.61, 95% CI: 1.15-2.25) of rs601681 had a nominally statistically significant increased risk of later age at natural menopause in comparison to the CC genotype. Subjects carrying either the heterozygous (CT) genotype (OR, 1.74; 95% CI, 1.21-2.50) or the homozygous recessive (TT...
Menopause is the endpoint of a process referred to as ovarian ageing. The mean age at menopause is a...
Menopause marks an upper limit of a female’s reproductive period. It is one of the key physiological...
Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which...
ABSTRACT: Menopause timing has a major impact on infertility and risk of disease. Younger age at nat...
Background: Environmental factors explain only a small part of the age variance at which menopause c...
ObjectiveTo determine if interindividual genetic variation in single-nucleotide polymorphisms (SNPs)...
In recent years, common genetic variants have been identified by genome-wide association studies (GW...
Introduction: A younger age at menarche and an older age at menopause are well established risk fact...
This is the author accepted manuscript. The final version is available from the publisher via the DO...
Reproductive ageing leading to menopause is characterized by depletion of follicles and its regulati...
Women become infertile approximately 10 years before menopause, and as more women delay childbirth i...
The onset of menopause has important implications on women's fertility and health. We previously ide...
Menopause timing has a substantial impact on infertility and risk of disease, including breast cance...
Introduction: A younger age at menarche and an older age at menopause are well established risk fact...
Menopause timing has a substantial impact on infertility and risk of disease, including breast cance...
Menopause is the endpoint of a process referred to as ovarian ageing. The mean age at menopause is a...
Menopause marks an upper limit of a female’s reproductive period. It is one of the key physiological...
Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which...
ABSTRACT: Menopause timing has a major impact on infertility and risk of disease. Younger age at nat...
Background: Environmental factors explain only a small part of the age variance at which menopause c...
ObjectiveTo determine if interindividual genetic variation in single-nucleotide polymorphisms (SNPs)...
In recent years, common genetic variants have been identified by genome-wide association studies (GW...
Introduction: A younger age at menarche and an older age at menopause are well established risk fact...
This is the author accepted manuscript. The final version is available from the publisher via the DO...
Reproductive ageing leading to menopause is characterized by depletion of follicles and its regulati...
Women become infertile approximately 10 years before menopause, and as more women delay childbirth i...
The onset of menopause has important implications on women's fertility and health. We previously ide...
Menopause timing has a substantial impact on infertility and risk of disease, including breast cance...
Introduction: A younger age at menarche and an older age at menopause are well established risk fact...
Menopause timing has a substantial impact on infertility and risk of disease, including breast cance...
Menopause is the endpoint of a process referred to as ovarian ageing. The mean age at menopause is a...
Menopause marks an upper limit of a female’s reproductive period. It is one of the key physiological...
Introduction: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which...