Multi-criteria decision analysis for the appraisal of medical needs : a pilot study – Short Report

24 p.ill.,FOREWORD 1 -- SYNTHESIS 2 -- 1 BACKGROUND 3 -- 1.1 EARLY ACCESS TO PROMISING MEDICINES FOR UNMET MEDICAL NEEDS 3 -- 1.2 THE PHILOSOPHY BEHIND THE LIST OF UNMET MEDICAL NEEDS 5 -- 1.3 MEDICAL VERSUS THERAPEUTIC AND SOCIETAL NEEDS 5 -- 2 OBJECTIVES OF THE STUDY 6 -- 3 METHODS 7 -- 3.1 PREVIOUS RESEARCH 7 -- 3.2 CRITERIA IN THE CURRENT MCDA APPROACH 7 -- 3.3 PHASES IN A MULTI-CRITERIA DECISION ANALYSIS 10 -- 3.4 METHODOLOGICAL CHOICES 12 -- 3.5 SUMMARY OF THE FEATURES OF THE TESTED MCDA 12 -- 3.6 TEST OF THE CHOSEN MCDA APPROACH 15 -- 4 RESULTS 16 -- 4.1 METHODOLOGICAL ISSUES RAISED BY THE MEMBERS OF THE CAIT / CATT 16 -- 4.2 DISCUSSION ABOUT THE CRITERIA SCORES 16 -- 4.3 DISCUSSION ABOUT THE RANKINGS 17 -- 5 DISCUSSION 18 -- 5.1 REFLECTIONS ON THE LEGAL FRAMEWORK FOR UNMET MEDICAL NEEDS 18 -- 5.2 MEDICAL NEEDS PROGRAMMES VERSUS UNMET MEDICAL NEEDS PROGRAM 19 -- 5.3 VALIDITY OF THE CURRENT STUDY 19 -- 5.4 DEALING WITH TWO LISTS OF NEEDS 19 -- 5.5 PRACTICAL TOOLS TO SUPPORT THE IMPLEMENTATION OF THE MCDA APPROACH.20 -- RECOMMENDATIONS 21 -- REFERENCES 2