Primerjava učinkovitosti selektivne laserske trabekuloplastike pri psevdoeksfoliacijskem glavkomu in primarnem glavkomu z odprtim zakotjem

Background. To compare the efficacy of selective laser trabeculoplasty (SLT) as treatment of pseudoexfoliation glaucoma (PG) and primary open-angle glaucoma (POAG) in a prospective clinical study. Methods. Ten eyes of 10 patients suffering from uncontrolled PG (PG group) and 10 eyes of 10 patients with uncontrolled POAG (POAG group) were treated with a frequency-doubled, Q-switched NdČYAG laser (532 nm). The baseline characteristics were similar inboth groups. The intraocular pressure (IOP) was measured before the treatment and 1day, 1 week, 1 month and 3, 6, 9, 12, 15, 18, 24, 30, and 36 months after the treatment. Success was defined as an IOP lowering, exceeding 20% of pretreatment IOP. Any modification of hypotensive medication led to exclude the eye from the study. Statistical analysis comparing the two groups was carried out using the independent-sample t test for continuous variables and the Log-Rank test for survival analysis. All tests were conducted considering p 0.05). Conclusions. SLT is an effective procedure for lowering IOP, although within 3years there has been a substantial failure rate in both PG and POAG eyes, andthe success seems to decline faster in PG eyes.Izhodišča. Primerjati učinkovitost selektivne laserske trabekuloplastike (SLT) pri zdravljenju psevdoeksfoliacijskega glavkoma (PG) in pri primarnem glavkomu z odprtim zakotjem (POAG) s prospektivno klinično raziskavo. Metode. 10 očes 10 bolnikov z neurejenim PG (skupina PG) in 10 očes 10 bolnikov z neurejenim POAG (skupina POAG) je bilo zdravljenih s frekvenčno podvojenim, Q-preklopljenim laserjem Nd:YAG (532 nm). Osnovne značilnosti so bile podobne v obeh skupinah. Očesni pritisk (IOP) je bil izmerjen pred zdravljenjem in nato 1 dan, 1 teden, 1 mesec ter 3, 6, 9, 12, 15, 18, 24, 30 in 36 mesecev po SLT. Uspeh je bil določen z znižanjem IOP, ki je bilo večje kot 20% glede na IOP pred zdravljenjem. Vsaka sprememba lokalnega protiglavkomskega zdravljenjaje vodila v izključitev očesa iz klinične raziskave. Statistična analiza primerjave dveh skupin je bila narejena s testom t neodvisnih vzorcev in testom Log-Rank za analizo preživetja. Pri vseh testih je bil p 0,05). Zaključki. SLT je učinkovita metoda za znižanje IOP, čeprav smo v 3 letih opazovanja ugotovili padec učinkovitosti tako pri očeh s PG kot pri očeh s POAG. Kaže, da uspešnost hitreje pada pri očeh s PG