The association between lumican gene polymorphisms and high myopia

[[abstract]]PurposesLumican (LUM) is one of the major extracellular matrix components of the sclera. Increasing evidence suggests that changes in the structure and composition of the sclera are major factors in regulating scleral integrity and axial elongation of the eye, as in myopia.Patients and methodsPatients (n=182; age range, 17-24 years) were with a myopic spherical equivalent (SE) >6.5 diopters (D) and the control group comprised individuals (n=78; age range, 17-25 years) were with a myopic SE