Risk perception and risk attitude in informed consent

The standard account of the (Kahneman and Tversky, 1979) is that attitude toward risk changes across gain or loss framings of outcomes. Weber and Bottom (1989) proposed an alternative account in which decision makers have stable risk attitudes, but changing risk perceptions. Undergraduates were randomly assigned to read one of three hypothetical informed consent documents from a trial of a cholesterol-lowering drug. Documents used gain, loss or both framings to describe expected benefits. Respondents rated riskiness of participation and non-participation in the trial and made a choice about whether they would participate in the trial.