Distribution of injected I¹³¹ labeled antibody to dog fibrin in tumor-bearing dogs /

Radioiodine labeled antibody to dog fibrin was prepared and injected intravenously into 28 dogs with spontaneous tumors. The I¹³¹ content of tumor tissue was determined 3 days later. Most tumors showed no preferential concentration of I¹³¹. In a few instances preferential I¹³¹ localization was found, and in at least one tumor it was great enough to suggest that if similar localization occurs in some types of human cancer, highly radioactive antibody of this type might be a useful tool for selective radiation of malignant tumor tissue."UR-569 ; Biology and Medicine ; TID-4500, (15th ed.).""Contract W-7401-eng-49 between the U.S. Atomic Energy Commission and the University of Rochester, administered by the Department of Radiation Biology of the School of Medicine and Dentistry.""Date completed: 3/25/60 ; Date of Issue: 4/12/60."Includes bibliographical references (page 13).Radioiodine labeled antibody to dog fibrin was prepared and injected intravenously into 28 dogs with spontaneous tumors. The I¹³¹ content of tumor tissue was determined 3 days later. Most tumors showed no preferential concentration of I¹³¹. In a few instances preferential I¹³¹ localization was found, and in at least one tumor it was great enough to suggest that if similar localization occurs in some types of human cancer, highly radioactive antibody of this type might be a useful tool for selective radiation of malignant tumor tissue.Mode of access: Internet