A coercion semantics of a programming language with subtyping is typically defined on typing derivations rather than on typing judgments. To avoid semantic ambiguity, such a semantics is expected to be coherent, i.e., independent of the typing derivation for a given typing judgment. In this article we present heterogeneous, biorthogonal, step-indexed logical relations for establishing the coherence of coercion semantics of programming languages with subtyping. To illustrate the effectiveness of the proof method, we develop a proof of coherence of a type-directed, selective CPS translation from a typed call-by-value lambda calculus with delimited continuations and control-effect subtyping. The article is accompanied by a Coq formalization th...