On-line model checking is a variant of model checking that evaluates properties of a system concurrently while deployed, which allows overcoming limitations of inaccurate system models. In this paper we conduct a laser tracheotomy case study to evaluate the feasibility of using the statistical model checker UPPAAL-SMC for on-line model checking in a medical application. Development of automatic on-line model checking relies on the precision of the prediction and real-time capabilities as real-time requirements must be met. We evaluate the case study with regards to these qualities and our results show that using UPPAAL-SMC in an on-line model checking context is practical: relative prediction errors were only 2% on average and guarantees co...