Relationship of Associated Cardiovascular Risk Factors and Chronic Kidney Disease with Participants Enrolled in the National Kidney Foundation of Hawai\u27i Kidney Early Detection Screening (KEDS) Program

Objective The objective of this study was to further examine the relationship of associated cardiovascular risk factors and chronic kidney disease (CKD) with a large cross-sectional sample of Native Hawaiians, Japanese, Chinese, Filipino, and White participants who were enrolled in the National Kidney Foundation of Hawai\u27i Kidney Early Detection Screening (KEDS) program. Methods Data for this cross-sectional study was collected between 2006 and 2009 from the National Kidney Foundation of Hawaii (NKFH). Nine hundred and fifteen participants who attended the NKFH KEDS program were 18 years and older, and residents of the State of Hawaii. Data included demographic information, clinical risk factors, anthropometric measurements, and lab values. Microalbuminuria was used as an indicator for CKD. Descriptive analysis using frequencies, means, and standard deviations, chi-square tests, and ANOVA were conducted to examine the differences in cardiovascular disease (CVD) risk factors and normal and abnormal microalbuminuria groups. A multivariate hierarchical logistic regression model was used to identify the CV risk factors associated with abnormal microalbuminuria. The Hosmer and Lemeshow Goodness of Fit test and R-2-type indices examined the fit of the regression model to the data. Results Significant results related to microalbuminuria included BMI (p=0.004), glucose (p=.004), and Japanese ethnicity (p=.008). Conclusion The findings support the need to address CVD risk factors in NKFH KEDS program. Keywords: chronic kidney disease, CVD risk factors, microalbuminuria, Asians, Native Hawaiians Pacific Islander