Endocrinology of equine metabolic pathophysiology

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.Title from title screen of research.pdf file (viewed on July 31, 2007)Vita.Thesis (Ph. D.) University of Missouri-Columbia 2006.Obesity in horses is associated with a number of maladies including insulin resistance and laminitis; therefore studies investigating the metabolic physiology of equine were done. In our first study, we characterized the profiles of leptin, insulin-like growth factor-1, and thyroid stimulating hormone in mares and foals in the peri-parturient period. The highest concentration of all hormones was found in the first milk sample, which is in agreement with other equine research. This study also provided the first data on leptin concentrations in the neonatal foal. In our second study, we examined the link between leptin and adrenocorticoid hormones by administering the mineralocorticoid receptor antagonist spironolactone to pony mares. We found no change in cortisol or leptin concentrations between treatments, but did see a trend for increased aldosterone concentrations in the blood of spironolactone treated ponies over time. Further work is necessary to elucidate the relationship between leptin and adrenocorticoids in equine. In our third study, we investigated the effects lipoic acid supplementation on blood glucose and insulin responses, as well as leptin concentrations in pony mares. We found no differences between treatments for blood glucose or leptin concentrations during a glucose tolerance test; however there was a trend for decreased insulin concentrations. These results suggest that lipoic acid may improve insulin effectiveness and warrant further investigation into the potential benefits of lipoic acid supplementation in the management of insulin resistance in equine.Includes bibliographical reference