Decrease in APP and CP mRNA expression supports impairment of iron export in Alzheimer's disease patients

Guerreiro, C
Silva, B
Crespo, A
Marques, L
Costa, S
Timóteo, A
Marcelino, E
Maruta, C
Vilares, A
Matos, M
Couto, F
Faustino, P
Verdelho, A
Guerreiro, M
Herrero Valverde, A
Costa, C
Mendonça, A
Martins, M
Costa, L

Open link

Publication date

January 2015

DOI

10.1016/j.bbadis.2015.07.017

Publisher

Elsevier BV

ISSN

0925-4439

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder of still unknown etiology and the leading cause of dementia worldwide. Besides its main neuropathological hallmarks, a dysfunctional homeostasis of transition metals has been reported to play a pivotal role in the pathogenesis of this disease. Dysregulation of iron (Fe) metabolism in AD has been suggested, particularly at the level of cellular iron efflux. Herein, we intended to further clarify the molecular mechanisms underlying Fe homeostasis in AD. In order to achieve this goal, the expression of specific Fe metabolism-related genes directly involved in Fe regulation and export was assessed in peripheral blood mononuclear cells (PBMCs) from 73AD patients and 74 controls by quantita...