We constructed a model for the initiation of the action potential (AP) in a damaged axon initial segment(AIS). We modelled the full axon including the AIS with a system of partial differential equations that we solved numerically. The damage was modelled on the AIS by having selected voltage-gated sodium channels affected by a coupled left-shift (CLS) of their activation and inactivation gating dynamics. We found that increased CLS lowered the threshold of spike initiation. We also found that CLS decreased the delay of spike initiation, especially for longer AIS. We also found that variability in the initiation timing increased with CLS. We also explored the effect of the geometry of the AIS on the initiation, finding that decreasing the r...
Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment ch...
<p>Left: model with simplified soma-axon geometry. Right: cortical pyramidal cell model with morphol...
Fundamental to an understanding of how neurons integrate synaptic input is the knowledge of where wi...
The effects of physical trauma to nerve cells are of great interest in neuroscience and neuromedicin...
International audienceIn most vertebrate neurons, spikes initiate in the axonal initial segment (AIS...
<p>A, Simplified electrical model of the axon initial segment (used for theoretical analysis but not...
In most vertebrate neurons, spikes initiate in the axonal initial segment (AIS). When recorded in th...
Action potentials (APs) in the soma of central neurons exhibit a sharp, step-like onset dynamics, wh...
Abstract Neural tissue injuries render voltage-gated Na+ channels (Nav) leaky, thereby altering exci...
Somatic action potentials (AP) of cortical pyramidal neurons have characteristically high onset-rapi...
International audienceThe axon initial segment (AIS) is a specialised region of the axon where the a...
The dynamics and the sharp onset of action potential (AP) generation have recently been the subject ...
The dynamics and the sharp onset of action potential (AP) generation have recently been the subject ...
International audienceClassically, action potentials are initiated at the axon initial segment (AIS)...
International audienceIn most vertebrate neurons, action potentials are triggered at the distal end ...
Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment ch...
<p>Left: model with simplified soma-axon geometry. Right: cortical pyramidal cell model with morphol...
Fundamental to an understanding of how neurons integrate synaptic input is the knowledge of where wi...
The effects of physical trauma to nerve cells are of great interest in neuroscience and neuromedicin...
International audienceIn most vertebrate neurons, spikes initiate in the axonal initial segment (AIS...
<p>A, Simplified electrical model of the axon initial segment (used for theoretical analysis but not...
In most vertebrate neurons, spikes initiate in the axonal initial segment (AIS). When recorded in th...
Action potentials (APs) in the soma of central neurons exhibit a sharp, step-like onset dynamics, wh...
Abstract Neural tissue injuries render voltage-gated Na+ channels (Nav) leaky, thereby altering exci...
Somatic action potentials (AP) of cortical pyramidal neurons have characteristically high onset-rapi...
International audienceThe axon initial segment (AIS) is a specialised region of the axon where the a...
The dynamics and the sharp onset of action potential (AP) generation have recently been the subject ...
The dynamics and the sharp onset of action potential (AP) generation have recently been the subject ...
International audienceClassically, action potentials are initiated at the axon initial segment (AIS)...
International audienceIn most vertebrate neurons, action potentials are triggered at the distal end ...
Central neurons initiate action potentials (APs) in the axon initial segment (AIS), a compartment ch...
<p>Left: model with simplified soma-axon geometry. Right: cortical pyramidal cell model with morphol...
Fundamental to an understanding of how neurons integrate synaptic input is the knowledge of where wi...
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