Adult skeletal muscles can regenerate after injury due to the presence of satellite cells, a quiescent population of myogenic progenitor cells characterized by expressing the transcription factor Pax7. Once activated, satellite cells repair the muscle damage and replenish the stem cell niche due to the coordinated function of several transcription factors including Pax7 and the myogenic regulatory factors (MRFs). MRFs are skeletal muscle-specific transcription factors that can convert non-muscle cells into the myogenic lineage. MRFs are known to cooperate with other transcription factors in regulating the complex transcriptional network driving myogenic differentiation of muscle progenitors. The Six4 transcription factor emerges as a strong...
MRF4 is one of four skeletal muscle specific regulatory genes, (the other three genes being MyoD, my...
In mammals, several genetic pathways have been characterized that govern engagement of multipotent e...
MRF4 is one of four skeletal muscle specific regulatory genes, (the other three genes being MyoD, my...
The Six family of transcription factors counts six members in vertebrates (from Six1 to Six6). Six1 ...
Proper development of skeletal muscle occurs through a highly complex process where activation and r...
Precise regulation of gene expression is crucial to myogenesis and is thought to require the coopera...
Skeletal myogenesis is under the control of a combinatorial network of transcription factors. It has...
Quiescent satellite cells are myogenic progenitors that enable regeneration of skeletal muscle. One ...
<div><p>Quiescent satellite cells are myogenic progenitors that enable regeneration of skeletal musc...
Quiescent satellite cells are myogenic progenitors that enable regeneration of skeletal muscle. One ...
Satellite cells are an adult stem cell population that provide for the regeneration of skeletal musc...
International audiencePax7 expression marks stem cells in developing skeletal muscles and adult sate...
International audiencePax7 expression marks stem cells in developing skeletal muscles and adult sate...
Pax7 expression marks stem cells in developing skeletal muscles and adult satellite cells during hom...
AbstractAdult skeletal muscles in vertebrates are composed of different types of myofibers endowed w...
MRF4 is one of four skeletal muscle specific regulatory genes, (the other three genes being MyoD, my...
In mammals, several genetic pathways have been characterized that govern engagement of multipotent e...
MRF4 is one of four skeletal muscle specific regulatory genes, (the other three genes being MyoD, my...
The Six family of transcription factors counts six members in vertebrates (from Six1 to Six6). Six1 ...
Proper development of skeletal muscle occurs through a highly complex process where activation and r...
Precise regulation of gene expression is crucial to myogenesis and is thought to require the coopera...
Skeletal myogenesis is under the control of a combinatorial network of transcription factors. It has...
Quiescent satellite cells are myogenic progenitors that enable regeneration of skeletal muscle. One ...
<div><p>Quiescent satellite cells are myogenic progenitors that enable regeneration of skeletal musc...
Quiescent satellite cells are myogenic progenitors that enable regeneration of skeletal muscle. One ...
Satellite cells are an adult stem cell population that provide for the regeneration of skeletal musc...
International audiencePax7 expression marks stem cells in developing skeletal muscles and adult sate...
International audiencePax7 expression marks stem cells in developing skeletal muscles and adult sate...
Pax7 expression marks stem cells in developing skeletal muscles and adult satellite cells during hom...
AbstractAdult skeletal muscles in vertebrates are composed of different types of myofibers endowed w...
MRF4 is one of four skeletal muscle specific regulatory genes, (the other three genes being MyoD, my...
In mammals, several genetic pathways have been characterized that govern engagement of multipotent e...
MRF4 is one of four skeletal muscle specific regulatory genes, (the other three genes being MyoD, my...