The thesis investigates synthetic routes to enediynes, a class of compounds of widespread interest due to their unusual molecular structure, potent antitumor activity and interesting mode of action. The preparation of eleven and twelve membered ring enediynes bearing oxy substituents in both propargylic positions is described via a novel intramolecular samarium diiodide coupling reaction of $\alpha,\beta$-unsaturated acetylenic aldehydes.* Other synthetic strategies based on various cyclization reactions (crossed aldol condensation, acetylide electrophile reaction, silicon directed electrophilic substitution and low valent palladium coupling) were examined.* A new anti-Brook rearrangement of acetophenone enol ethers was discovered that allo...
The synthesis of 3,4-ene-1,5-diynes, the key structural moiety present in several naturally occurrin...
This work consists of four consecutive parts, each dealing with syntheses of structurally diverse co...
Continuing the theme of the preceding article, this paper describes the synthesis and chemical prope...
Following the discovery of the enediyne anticancer antibiotics, investigations were initiated direct...
grantor: University of TorontoIn this thesis it was hypothesized that the incorporation of...
The kedarcidin and C1027 chromophores are formidable targets for total synthesis. Herein, we describ...
University of Minnesota Ph.D. dissertation. August 2016. Major: Chemistry. Advisor: Thomas Hoye. 1 c...
Enediyne natural products are among the most potent antitumor agents known today. Numerous synthetic...
The complex molecular structure and interesting activation mechanisms of naturally occurring enediyn...
This thesis is divided into three parts. Part 1 describes the chemistry of dilithium (trimethylstann...
This dissertation describes research pertaining to the synthesis of natural products and reaction me...
This thesis presents investigations of alkoxy and aminyl radical cyclizations onto silyl enol ethers...
A process for synthesizing enediynes is provided. Specifically, the formed enediynes contain a hex-3...
Cyclodeca-1,5-diyn-3-ene, the parent core of naturally occurring 10-membered ring enediyne antitumor...
This thesis describes the Smith group\u27s synthetic efforts toward the tedanolides, marine natural ...
The synthesis of 3,4-ene-1,5-diynes, the key structural moiety present in several naturally occurrin...
This work consists of four consecutive parts, each dealing with syntheses of structurally diverse co...
Continuing the theme of the preceding article, this paper describes the synthesis and chemical prope...
Following the discovery of the enediyne anticancer antibiotics, investigations were initiated direct...
grantor: University of TorontoIn this thesis it was hypothesized that the incorporation of...
The kedarcidin and C1027 chromophores are formidable targets for total synthesis. Herein, we describ...
University of Minnesota Ph.D. dissertation. August 2016. Major: Chemistry. Advisor: Thomas Hoye. 1 c...
Enediyne natural products are among the most potent antitumor agents known today. Numerous synthetic...
The complex molecular structure and interesting activation mechanisms of naturally occurring enediyn...
This thesis is divided into three parts. Part 1 describes the chemistry of dilithium (trimethylstann...
This dissertation describes research pertaining to the synthesis of natural products and reaction me...
This thesis presents investigations of alkoxy and aminyl radical cyclizations onto silyl enol ethers...
A process for synthesizing enediynes is provided. Specifically, the formed enediynes contain a hex-3...
Cyclodeca-1,5-diyn-3-ene, the parent core of naturally occurring 10-membered ring enediyne antitumor...
This thesis describes the Smith group\u27s synthetic efforts toward the tedanolides, marine natural ...
The synthesis of 3,4-ene-1,5-diynes, the key structural moiety present in several naturally occurrin...
This work consists of four consecutive parts, each dealing with syntheses of structurally diverse co...
Continuing the theme of the preceding article, this paper describes the synthesis and chemical prope...