Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavailability to assess the mechanisms involved in the glucoregulatory action of RSV in high-fat diet (HFD)-fed diabetic wild type mice. Administration of RSV for 5 weeks reduced the development of glucose intolerance, and increased portal vein concentrations of both Glucagon-like peptid-1 (GLP-1) and insulin, and intestinal content of active GLP-1. This was associated with increased levels of colonic proglucagon mRNA transcripts. RSV-mediated glucoregulation required a functional GLP-1 receptor (Glp1r) as neither glucose nor...
BackgroundResveratrol (RSV) plays a vital role in alleviating various stresses and improving intesti...
Resveratrol (RSV), a natural polyphenol, has been shown to exert activity against obesity and relate...
Resveratrol (3,5,4'-trihydroxystilbene; RSV) is one kind of polyphenolic phytoalexin that has many e...
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targe...
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targe...
Insulin resistance participates in the glycaemic control disruption in type 2 diabetes mellitus (T2D...
Abstract Resveratrol is a natural polyphenolic compound that activates nicotinamide adenosine dinuc...
<p><b>A)</b> Glycemic profiles (mg/dL) of high fat diet-fed diabetic mice treated with RSV (squares)...
The regulation of postprandial blood glucose (PBG) levels is an effective therapeutic method to trea...
Diabetes mellitus is highly prevalent worldwide. High-fat-diet (HFD) consumption can lead to liver f...
International audienceThe polyphenols resveratrol (RSV) and curcumin (Cur) are phytoalexines and nat...
Resveratrol (RSV) has anti-inflammatory and anti-oxidant actions which may contribute to its cardiov...
Resveratrol (RSV) has anti-inflammatory and anti-oxidant actions which may contribute to its cardiov...
High-fat diet (HFD)-feeding induces changes in the microbiome and increases intestinal permeability ...
Oral administration of resveratrol is able to ameliorate the progression of diabetic nephropathy (DN...
BackgroundResveratrol (RSV) plays a vital role in alleviating various stresses and improving intesti...
Resveratrol (RSV), a natural polyphenol, has been shown to exert activity against obesity and relate...
Resveratrol (3,5,4'-trihydroxystilbene; RSV) is one kind of polyphenolic phytoalexin that has many e...
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targe...
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targe...
Insulin resistance participates in the glycaemic control disruption in type 2 diabetes mellitus (T2D...
Abstract Resveratrol is a natural polyphenolic compound that activates nicotinamide adenosine dinuc...
<p><b>A)</b> Glycemic profiles (mg/dL) of high fat diet-fed diabetic mice treated with RSV (squares)...
The regulation of postprandial blood glucose (PBG) levels is an effective therapeutic method to trea...
Diabetes mellitus is highly prevalent worldwide. High-fat-diet (HFD) consumption can lead to liver f...
International audienceThe polyphenols resveratrol (RSV) and curcumin (Cur) are phytoalexines and nat...
Resveratrol (RSV) has anti-inflammatory and anti-oxidant actions which may contribute to its cardiov...
Resveratrol (RSV) has anti-inflammatory and anti-oxidant actions which may contribute to its cardiov...
High-fat diet (HFD)-feeding induces changes in the microbiome and increases intestinal permeability ...
Oral administration of resveratrol is able to ameliorate the progression of diabetic nephropathy (DN...
BackgroundResveratrol (RSV) plays a vital role in alleviating various stresses and improving intesti...
Resveratrol (RSV), a natural polyphenol, has been shown to exert activity against obesity and relate...
Resveratrol (3,5,4'-trihydroxystilbene; RSV) is one kind of polyphenolic phytoalexin that has many e...