PtCl2-catalyzed hydrative cyclization of trialkyne functionalities to form bicyclic spiro ketones

[[abstract]]Triple rounds: A regioselective hydrative cyclization of triynes has been developed to give bicyclic β-hydroxy spiro ketones, which undergo subsequent dehydration to give the β,γ- unsaturated ketones (see scheme). Model reactions suggest that this platinum catalysis includes two selective hydrations, an alkyne insertion, and an aldol condensation.[[fileno]]2010327010004[[department]]化學