Radiochemical characteristics and Biodistribution for 99mTc labeled complexes with schiff-base Ligands containing the ONNNO donor atom set

[[abstract]]©2002 SNM - A series of analogues of Schiff-base containing the ONNNO donor atom set were synthesized deriving from the reaction of salicylaldehyde and the triamine compounds of diethylenetriamine, diproplylenetriamine, and ethylene propylenetriamine, and the correspondent triamine compounds but bearing with middle N-bonded pyridinyl. Complexations were made at ambient temperature by reaction of the ligands with 99mTc-pertechnatate in the presence of stannous tartrate solution under different pH buffers. The radiochemical characteristics of the 99mTc-labeled complexes with the various ligands were investigated by the techniques of solvent extraction, thin layer chromatography and paper electrophoresis.Biodistribution of four 99mTc labeled complexes were studied on C3H/HeN mice. Correlation of biodistribution with radiochemical characteristics for the 99mTc labeled complexes is discussed.[[department]]生醫工程與環境科學