Signaling via the conserved WNT/β-CATENIN pathway controls diverse developmental processes. To explore its potential role in the ovary, we investigated the expression of WNTs, frizzled (FZD) receptors and other pathway components in human cumulus cells obtained from oocytes collected for in vitro fertilization. Proteins were detected in cultured cells using immunofluorescence microscopy. Protein–protein interactions were analyzed by means of immunoprecipitation. WNT2, FZD2, FZD3 and FZD9 were identified but WNT1, WNT4 and FZD4 were not detected. WNT2 is co-expressed with FZD2, FZD3 and FZD9. Co-immunoprecipitation using WNT2 antibody demonstrated that WNT2 interacts with both FZD3 and FZD9, but only FZD9 antibody precipitated WNT2. We also ...
Mouse F9 cells differentiate into primitive endoderm (PrE) following the activation of the canonical...
The Wnt/β-catenin signaling pathway regulates genes involved in proliferation and apoptosis. These t...
Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/in...
Ovarian development in mammals is considered as a default process, arising only in the absence of Sr...
WNTs are secreted extracellular signaling molecules that transduce their signals by binding to G pro...
WNTs are secreted extracellular signaling molecules that transduce their signals by binding to G pro...
Animals’ Wnt signaling pathways are highly preserved signal transduction pathways, which play a cruc...
AbstractThe wnt signal transduction pathway is involved in many differentiation events during embryo...
One of the early surprises in the study of cell adhesion was the discovery that β-catenin plays dual...
WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological ...
AbstractMutual adhesion of animal cells is intimately linked to Wnt signaling through a shared compo...
Canonical Wnt signaling, below the Fz/LRP receptor complex, induces the stabilization of β-catenin v...
All the major components of the WNT signalling pathway are expressed in female germ cells and embryo...
The differential activation of Wnt pathways (canonical: Wnt/β-catenin; non-canonical: planar cell po...
AbstractAutocrine Wnt signaling in the mouse mammary tumor virus model was the first identified mech...
Mouse F9 cells differentiate into primitive endoderm (PrE) following the activation of the canonical...
The Wnt/β-catenin signaling pathway regulates genes involved in proliferation and apoptosis. These t...
Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/in...
Ovarian development in mammals is considered as a default process, arising only in the absence of Sr...
WNTs are secreted extracellular signaling molecules that transduce their signals by binding to G pro...
WNTs are secreted extracellular signaling molecules that transduce their signals by binding to G pro...
Animals’ Wnt signaling pathways are highly preserved signal transduction pathways, which play a cruc...
AbstractThe wnt signal transduction pathway is involved in many differentiation events during embryo...
One of the early surprises in the study of cell adhesion was the discovery that β-catenin plays dual...
WNT/Frizzled receptor (FZD) signaling pathways are pivotal for physiological and pathophysiological ...
AbstractMutual adhesion of animal cells is intimately linked to Wnt signaling through a shared compo...
Canonical Wnt signaling, below the Fz/LRP receptor complex, induces the stabilization of β-catenin v...
All the major components of the WNT signalling pathway are expressed in female germ cells and embryo...
The differential activation of Wnt pathways (canonical: Wnt/β-catenin; non-canonical: planar cell po...
AbstractAutocrine Wnt signaling in the mouse mammary tumor virus model was the first identified mech...
Mouse F9 cells differentiate into primitive endoderm (PrE) following the activation of the canonical...
The Wnt/β-catenin signaling pathway regulates genes involved in proliferation and apoptosis. These t...
Wnt/β-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/in...