Mutant and chimeric recombinant plasminogen activators

Generation and characterization of urokinase receptor-deficient mice

Dewerchin, Mieke
Van Nuffelen, An
Wallays, Goedele
Bouché, A
Moons, Lieve
Carmeliet, Peter
Mulligan, RC
Collen, Desire

February 1996

Mice homozygously deficient for the urokinase-type plasminogen activator (u-PA) receptor (u-PAR-1-) ...

Expression of a novel chimeric protein containing the A chain of tissue-type plasminogen activator and the B chain of pro-urokinase in insect cells using the baculovirus system

Zhao, CM
Zhang, HT
Hu, MH

January 1999

A hybrid cDNA tu-pa, which contains Ser1-Thr263 of tissue-type plasminogen activator (t-PA) and Ser1...

Characterization of a Recombinant Fusion Protein of the Finger Domain of Tissue-type Plasminogen Activator with a Truncated Single

Chain Urokinase-type
Plasminogen Activator
Dirk Gheysens
H. Roger Lijnens
Laurent Pierardll
Franqoise De Forestas
Eddy Demarsins
Paul Jacobsll
Michel De Wildes
Alex Bollenll
Desire Collene

October 2016

Human recombinant single chain urokinase-type plasminogen activator (recombinant scu-PA) and a hy-br...

Mutant and chimeric recombinant plasminogen activators

Pierard, L.
Jacobs, P.
Gheysen, D.
Hoylaerts, M.
Cravador, A.
Herzog, A.
Collen, D.
Bollen, A.

January 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Mutant and chimeric recombinant plasminogen activators. Production in eukaryotic cells and preliminary characterization.

Pierard, Laurent
Jacobs, Paul
Gheysen, Dirk
Hoylaerts, Marc
André, Bruno
Topisirović, L.
Cravador, Alfredo
De Foresta, Françoise M.
Herzog, Albert
Collen, Désiré

August 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Mutant and chimeric recombinant plasminogen activators. Production in eukaryotic cells and preliminary characterization.

Pierard, Luc
Jacobs, P.
Gheysen, D.
Hoylaerts, M.
Andre, B.
Topisirovic, L.
Cravador, A.
de Foresta, F.
Herzog, A.
Collen, D.

January 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Mutant and chimeric recobinant plasminogen activatorsproduction in eukaryotic cellsand preliminary characterization

Pierard, L.
Jacobs, P.
Gheysen, D.
Hoylaerts, M.
Andre, B.
Topisirovic, L.
Cravador, A.
Deforesta, F.
Herzog, A.
Collen, D.
Dewilde, M.
Bollen, A.

January 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Mutant and chimeric recobinant plasminogen activatorsproduction in eukaryotic cellsand preliminary characterization

Pierard, L.
Jacobs, P.
Gheysen, D.
Hoylaerts, M.
Andre, B.
Topisirovic, L.
Cravador, A.
Deforesta, F.
Herzog, A.
Collen, D.
Dewilde, M.
Bollen, A.

January 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Characterisation of a mutant of recombinant human single chain urokinase-type plasminogen activator (scu-PA), obtained by substitution of arginine 156 and lysine 158 with threonine

Lijnen, Henri Roger
Collen, Désiré
Gheysen, Dirk
de Foresta, Françoise
Pierard, Laurent
Jacobs, Paul
Bollen, Alex

January 1988

A mutant of recombinant single chain urokinase-type plasminogen activator (rscu-PA) was constructed ...

Development of new thrombolytic agents using recombinant DNA technology.

Pierard, Luc
Bollen, A.

January 1990

The increasing incidence of thromboembolic diseases has sustained the search for new agents able to ...

Characterization of a recombinant fusion protein of the finger domain of tissue-type plasminogen activator with a truncated single chain urokinase-type plasminogen activator.

Gheysen, D.
Lijnen, H. R.
Pierard, Luc
de Foresta, F.
Demarsin, E.
Jacobs, P.
De Wilde, Marc
Bollen, A.
Collen, D.

January 1987

Human recombinant single chain urokinase-type plasminogen activator (recombinant scu-PA) and a hybri...

BriefRapid Communication A Recombinant, Chimeric Enzyme With a Novel Mechanism of Action Leading to Greater Potency and Selectivit Than Tissue-Type Plasminogen Activator

Jeff H. Robinson
Phd Michael
J. Browne
Phd Janet
E. Carey
Bsc Paul
D. Chamberlain
Conrad G. Chapman
Mibiol David
W. Cronk
Mibiol Ian Dodd
Claire Entwisle
Mibiol Ashiq
F. Esmail
Phd S. Barrett Kalindjian
Richard A. G. Smith
Shelagh Wilson

October 2016

Background. Early intervention with thrombolytic agents has been shown unequivocally to reduce morta...

Characterization of a chimaeric plasminogen activator obtained by insertion of the second kringle structure of tissue-type plasminogen activator (amino acids 173 through 262) between residues Asp130 and Ser139 of urokinase-type plasminogen activator.

Lijnen, H. R.
Pierard, Luc
Reff, M. E.
Gheysen, D.

January 1988

A chimaeric recombinant plasminogen activator (rscu-PA- K2) obtained by insertion of the second krin...

Characterization of a chimaeric plasminogen activator obtained by insertion of the second kringle structure of tissue-type plasminogen activator (amino acids 173 through 262) between residues Asp130 and Ser139 of urokinase-type plasminogen activator

Lijnen, Henri Roger
Pierard, Laurent
Reff, Mitchell
Gheysen, Dirk

December 1988

A chimaeric recombinant plasminogen activator (rscu-PA-∇K2) obtained by insertion of the second krin...

Mutations affecting the activity of urokinase-type plasminogen activator

Lance S. Davidow
Dennis R. Dumais
Adrienne P. Smyth
Jonathan Greer
Donald T. Moir

September 2016

'To whom correspondence should be addressed Mutagenesis throughout the single-chain urokinase-t...

Generation and characterization of urokinase receptor-deficient mice

Dewerchin, Mieke
Van Nuffelen, An
Wallays, Goedele
Bouché, A
Moons, Lieve
Carmeliet, Peter
Mulligan, RC
Collen, Desire

February 1996

Mice homozygously deficient for the urokinase-type plasminogen activator (u-PA) receptor (u-PAR-1-) ...

Expression of a novel chimeric protein containing the A chain of tissue-type plasminogen activator and the B chain of pro-urokinase in insect cells using the baculovirus system

Zhao, CM
Zhang, HT
Hu, MH

January 1999

A hybrid cDNA tu-pa, which contains Ser1-Thr263 of tissue-type plasminogen activator (t-PA) and Ser1...

Characterization of a Recombinant Fusion Protein of the Finger Domain of Tissue-type Plasminogen Activator with a Truncated Single

Chain Urokinase-type
Plasminogen Activator
Dirk Gheysens
H. Roger Lijnens
Laurent Pierardll
Franqoise De Forestas
Eddy Demarsins
Paul Jacobsll
Michel De Wildes
Alex Bollenll
Desire Collene

October 2016

Human recombinant single chain urokinase-type plasminogen activator (recombinant scu-PA) and a hy-br...

Mutant and chimeric recombinant plasminogen activators

Pierard, L.
Jacobs, P.
Gheysen, D.
Hoylaerts, M.
Cravador, A.
Herzog, A.
Collen, D.
Bollen, A.

January 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Mutant and chimeric recombinant plasminogen activators. Production in eukaryotic cells and preliminary characterization.

Pierard, Laurent
Jacobs, Paul
Gheysen, Dirk
Hoylaerts, Marc
André, Bruno
Topisirović, L.
Cravador, Alfredo
De Foresta, Françoise M.
Herzog, Albert
Collen, Désiré

August 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Mutant and chimeric recombinant plasminogen activators. Production in eukaryotic cells and preliminary characterization.

Pierard, Luc
Jacobs, P.
Gheysen, D.
Hoylaerts, M.
Andre, B.
Topisirovic, L.
Cravador, A.
de Foresta, F.
Herzog, A.
Collen, D.

January 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Mutant and chimeric recobinant plasminogen activatorsproduction in eukaryotic cellsand preliminary characterization

Pierard, L.
Jacobs, P.
Gheysen, D.
Hoylaerts, M.
Andre, B.
Topisirovic, L.
Cravador, A.
Deforesta, F.
Herzog, A.
Collen, D.
Dewilde, M.
Bollen, A.

January 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Mutant and chimeric recobinant plasminogen activatorsproduction in eukaryotic cellsand preliminary characterization

Pierard, L.
Jacobs, P.
Gheysen, D.
Hoylaerts, M.
Andre, B.
Topisirovic, L.
Cravador, A.
Deforesta, F.
Herzog, A.
Collen, D.
Dewilde, M.
Bollen, A.

January 1987

Mutant urokinase-type plasminogen activator (u-PA) genes and hybrid genes between tissue-type plasmi...

Characterisation of a mutant of recombinant human single chain urokinase-type plasminogen activator (scu-PA), obtained by substitution of arginine 156 and lysine 158 with threonine

Lijnen, Henri Roger
Collen, Désiré
Gheysen, Dirk
de Foresta, Françoise
Pierard, Laurent
Jacobs, Paul
Bollen, Alex

January 1988

A mutant of recombinant single chain urokinase-type plasminogen activator (rscu-PA) was constructed ...

Development of new thrombolytic agents using recombinant DNA technology.

Pierard, Luc
Bollen, A.

January 1990

The increasing incidence of thromboembolic diseases has sustained the search for new agents able to ...

Characterization of a recombinant fusion protein of the finger domain of tissue-type plasminogen activator with a truncated single chain urokinase-type plasminogen activator.

Gheysen, D.
Lijnen, H. R.
Pierard, Luc
de Foresta, F.
Demarsin, E.
Jacobs, P.
De Wilde, Marc
Bollen, A.
Collen, D.

January 1987

Human recombinant single chain urokinase-type plasminogen activator (recombinant scu-PA) and a hybri...

BriefRapid Communication A Recombinant, Chimeric Enzyme With a Novel Mechanism of Action Leading to Greater Potency and Selectivit Than Tissue-Type Plasminogen Activator

Jeff H. Robinson
Phd Michael
J. Browne
Phd Janet
E. Carey
Bsc Paul
D. Chamberlain
Conrad G. Chapman
Mibiol David
W. Cronk
Mibiol Ian Dodd
Claire Entwisle
Mibiol Ashiq
F. Esmail
Phd S. Barrett Kalindjian
Richard A. G. Smith
Shelagh Wilson

October 2016

Background. Early intervention with thrombolytic agents has been shown unequivocally to reduce morta...

Characterization of a chimaeric plasminogen activator obtained by insertion of the second kringle structure of tissue-type plasminogen activator (amino acids 173 through 262) between residues Asp130 and Ser139 of urokinase-type plasminogen activator.

Lijnen, H. R.
Pierard, Luc
Reff, M. E.
Gheysen, D.

January 1988

A chimaeric recombinant plasminogen activator (rscu-PA- K2) obtained by insertion of the second krin...

Characterization of a chimaeric plasminogen activator obtained by insertion of the second kringle structure of tissue-type plasminogen activator (amino acids 173 through 262) between residues Asp130 and Ser139 of urokinase-type plasminogen activator

Lijnen, Henri Roger
Pierard, Laurent
Reff, Mitchell
Gheysen, Dirk

December 1988

A chimaeric recombinant plasminogen activator (rscu-PA-∇K2) obtained by insertion of the second krin...

Mutations affecting the activity of urokinase-type plasminogen activator

Lance S. Davidow
Dennis R. Dumais
Adrienne P. Smyth
Jonathan Greer
Donald T. Moir

September 2016

'To whom correspondence should be addressed Mutagenesis throughout the single-chain urokinase-t...

Generation and characterization of urokinase receptor-deficient mice

Dewerchin, Mieke
Van Nuffelen, An
Wallays, Goedele
Bouché, A
Moons, Lieve
Carmeliet, Peter
Mulligan, RC
Collen, Desire

February 1996

Mice homozygously deficient for the urokinase-type plasminogen activator (u-PA) receptor (u-PAR-1-) ...

Expression of a novel chimeric protein containing the A chain of tissue-type plasminogen activator and the B chain of pro-urokinase in insect cells using the baculovirus system

Zhao, CM
Zhang, HT
Hu, MH

January 1999

A hybrid cDNA tu-pa, which contains Ser1-Thr263 of tissue-type plasminogen activator (t-PA) and Ser1...

Characterization of a Recombinant Fusion Protein of the Finger Domain of Tissue-type Plasminogen Activator with a Truncated Single

Chain Urokinase-type
Plasminogen Activator
Dirk Gheysens
H. Roger Lijnens
Laurent Pierardll
Franqoise De Forestas
Eddy Demarsins
Paul Jacobsll
Michel De Wildes
Alex Bollenll
Desire Collene

October 2016

Human recombinant single chain urokinase-type plasminogen activator (recombinant scu-PA) and a hy-br...

Mutant and chimeric recombinant plasminogen activators

Abstract

Extracted data

Mutant and chimeric recombinant plasminogen activators

Abstract

Extracted data

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