The effects of histamine receptors on IgG production in mice spleen cells and on mice collagen induced arthritis

publisher学位の種類：医学 学位授与年月日：1992/3/19 指導：田中, 清介 教授(Director: Prof. Tanaka, Seisuke) 報告番号：甲第207号 学内授与番号：医甲160 NDL書誌ID：000000266465[ABSTRACT] This study was carried out to investigate the role of histamine receptors in IgG production by spleen cells and the effects of histaminergic agonists on type II collagen-induced arthritis in mice. ConA-derived IgG production in the spleen cells from normal DBA/1J mice was dose-dependently suppressed by histamine. Moreover, both of histaminergic H_1 and H_2 agonists suppressed ConA-derived IgG production in the normal spleen cells.In CIA mice, spontaneous IgG production in the spleen cells was significantly higher than that in normal mice, but almost no ConA-derived production was observed in the spleen cells. Histamine induced suppression of the spontaneous IgG production in the spleen cells with CIA was weaker than the histamine-induced suppression on ConA-derived IgG production in the normal spleen cells. The H_2 -agonist-induced suppression on the IgG production in the CIA spleen cells was weaker than that in the normal spleen cells. On the other hand, the Hi -agonist-induced suppression on the IgG production in the CIA spleen cells was stronger than that in the normal spleen cells. Both H_1 and H_2 histaminergic agonists suppressed the incidence of onset with arthritis, arthritic index, and the titer of the anti-type II collagen antibody in CIA mice. The H_1 agonist had stronger benefical effects than the H_2 agonist. These findings suggested that both H_1 and H_2 histaminergic agonists had suppressive effects on in vitro IgG production in the spleen cells and also on in vivo disease activity in CIA