Influence of infertility diagnosis on pregnancy outcome in ART

Abstract Objective: To determine the influence of the infertility diagnosis on gestational age (GA) and birth weight (BW) of children conceived using assisted reproductive technology (ART). Design: Retrospective cohort. Setting: University-affiliated infertility clinic. Patients: Women with a singleton live birth following their first fresh ART cycle with autologous oocytes. Interventions: Patients were stratified into groups based on infertility diagnosis. GA and BW of their infants were compared. Main Outcome Measures: GA and BW of children conceived using ART. Results: 397 women were included. Average GA in the cohort was 38.7±2.3 weeks and average BW was 3301.5±633.8 grams. Maternal age, BMI, and parity were significantly different between groups. After controlling for these factors and stratifying by infertility diagnosis, there was no difference in GA or BW in infants conceived with ART. Conclusions: Contrary to previously reported data, there was no difference in GA or BW in infants conceived with ART when stratified by infertility diagnosis. Our results were not different from the national population; however GA was one week longer in our cohort than in the national ART database. These data suggest a difference exists between our cohort and the ART population at large. We propose that the main difference is our institution’s focus on single embryo transfer