Computer Adied Design , Synthesis and Biological Evaluation of Novel Acridine Derivatives a Topoisomerase I Inhibitors

A series of novel 9- anilinoacridines was designed and their molecular docking studies into the active site were examined as topoisomerase I inhibitor. Several compounds showed significant high simulation docking score.The designed compounds were synthesized and biologically evaluated against mammary carcinoma cell line (MCF-7), where compounds 8,11e,11f,13b,14b,14e and 14f showed significant inhibitory activity at a concentration 10ìg/mL). It appears that the in vitro activity of compounds 8,11e,11f,13b,14b,14e and 14f were consistent with their molecular modeling results, and compound 14b showed the highest activity with IC50 value of 7.8Cairo universit