New oxorhenium(V) complex with an aminothiazole ligand , and radiochemical behavior of its oxotechenetium(V) complex analog.

A [ReO(Amino)2OH] complex was successfully synthesized by the ligand exchange method using oxorhenuim gluconate with and an aminothiazole ligand. The complex was characterized using elemental analysis and IR, UV-Vis, NMR and mass spectroscopes. The technetium tracer 99mTcO-complex has also been synthesized by two methods using 99mTc-gluconate as a precursor or; by direct reduction. The radiochemical purity of the complex was over 95% as measured by thin layer chromatography. In vitro studies showed that the complex possessed good stability under physiological conditions. The partition coefficient indicated that the complex hydrophilic and the electrophoresis results showed that the complex neutral. Normal biodistributions of the 99mTc complex exhibit high lung, liver and spleen uptake of 27%, 11%, and 12%, uptake, respectively. Blood and lungs clearance was quite fast (% injection dose in blood and lungs 0.36% and 0.18%, respectively at 1 hr post-injection), while liver activity remained high for a longer period with 12% injection dose present at 1 hr post-injection. The radioactivity from the novel technetium complex was excreted mainly through the hepatobiliary system, which passed 35% of the complex at 1 hr post-injection, and partially through the kidneys