Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based on a limited number of toxicants. Within the embryonic stem cell-based novel alternative tests project, we developed a test battery framework that allows inclusion of any developmental toxicity assay and that explores the responses of such test systems to a wide range of drug-like compounds. We selected 28 compounds, including several biologics (e.g., erythropoietin), classical pharmaceuticals (e.g., roflumilast) and also six environmental toxicants. The chemical, toxicological and clinical data of this screen library were compiled. In order to determine a non-cytotoxic concentration range, cytotoxicity data were obtained for all compounds fr...
The use of animals to assess the safety of potentially hazardous chemicals and drugs for humans is b...
The application of alternative methods in developmental and reproductive toxicology is challenging i...
The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a test ba...
Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based ...
In the last years, different individual human embryonic stem cell-based developmental toxicity test ...
BACKGROUND: Information on the potential developmental toxicity (DT) of the majority of chemicals is...
Neurodevelopmental disorders affect 10-15% of children. For disorders like autism and attention defi...
The in vitro test battery of the European research consortium ESNATS ('novel stem cell-based test sy...
Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human exposome....
Many in vitro tests have been developed to screen for potential neurotoxicity. However, only few cel...
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard assessment. Si...
Identification of neurotoxic drugs and environmental chemicals is an important challenge. However, o...
Migration of neural crest cells (NCCs) is one of the pivotal processes of human fetal development. M...
Previously we showed a battery consisting of CALUX transcriptional activation assays, the ReProGlo a...
During life humans are exposed to diverse hazardous compounds, which can have toxicological effects....
The use of animals to assess the safety of potentially hazardous chemicals and drugs for humans is b...
The application of alternative methods in developmental and reproductive toxicology is challenging i...
The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a test ba...
Developmental toxicity in vitro assays have hitherto been established as stand-alone systems, based ...
In the last years, different individual human embryonic stem cell-based developmental toxicity test ...
BACKGROUND: Information on the potential developmental toxicity (DT) of the majority of chemicals is...
Neurodevelopmental disorders affect 10-15% of children. For disorders like autism and attention defi...
The in vitro test battery of the European research consortium ESNATS ('novel stem cell-based test sy...
Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human exposome....
Many in vitro tests have been developed to screen for potential neurotoxicity. However, only few cel...
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard assessment. Si...
Identification of neurotoxic drugs and environmental chemicals is an important challenge. However, o...
Migration of neural crest cells (NCCs) is one of the pivotal processes of human fetal development. M...
Previously we showed a battery consisting of CALUX transcriptional activation assays, the ReProGlo a...
During life humans are exposed to diverse hazardous compounds, which can have toxicological effects....
The use of animals to assess the safety of potentially hazardous chemicals and drugs for humans is b...
The application of alternative methods in developmental and reproductive toxicology is challenging i...
The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a test ba...