Improvement effect of tomato seeds and vitamin C on potassium bromate induced renal injury in rats

Fifty-four adult male of white albino rats (Sprague Dawley Strain) were injected with a single intraperitoneal dose of potassium bromate at level 125 mg /kg body weight to induce renal injury. Rats classified into non treated positive control group and five treated groups that were tomato seeds powder, tomato seeds extract, vitamin C, tomato seeds powder with vitamin C and tomato seeds extract with vitamin C groups. The study was conducted for ten weeks. The results revealed that, the treatment of renal injured rats with tomato seeds powder or extract with or without vitamin C showed improvement of nutritional results as a significant increase in final weight, weight gain and food intake compared to positive control group. The value of Food efficiency ratio (FER) was significantly increased in tomato seeds powder, tomato seeds extract, tomato seeds powder with vitamin C and tomato seeds extract with vitamin C groups compared to positive control group. Values of blood hemoglobin (HB), packed cell volume (PCV) and red blood cells; serum high density lipoprotein cholesterol (HDLc), glutathione transferase (GST), catalase & superoxide dismutase (SOD) , and kidney glutathione peroxidase (GPX) & glutathione transferase (GST) were significantly increased in all treated groups compared to positive control group. The values of serum cholesterol, cholesterol/HDLc ratio, triglyceride, low density lipoprotein cholesterol (LDLc), creatinine, uric acid, urea & nitric oxide (NO) and kidney malondialdehyde (MDA) were significantly decreased compared to positive control group. White blood cells was significantly increased in tomato seeds powder with vitamin C and tomato seeds extract with vitamin C groups while the value of serum very low density lipoprotein cholesterol (VLDLc) was significantly decreased in tomato seeds powder, tomato seeds extract, tomato seeds powder with vitamin C and tomato seeds extract with vitamin C groups compared to positive control group