Synthesis and Investigation of Tryptophan-Amphotericin B Conjugates
- Zumbuehl, Andréas
- Stano, Pasquale
- Sohrmann, Marc
- Dietiker, Rolf
- Peter, Mathias
- Carreira, Erick M.
Publication date
January 2009
DOI Publisher
Wiley ISSN
1439-4227 Citation count (estimate)
7Abstract
Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes
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