Depletion of anti-Gal antibodies by the intravenous infusion of Gal type 2 and 6 glycoconjugates in baboons
- Teranishi, Katsuhito
- Alwayn, Ian P J
- Buehler, Leo Hans
- Gollackner, Bernd
- Knosalla, Christoph
- Huck, Jennifer
- Duthaler, Rudolf
- Katopodis, Andreas
- Sachs, David H
- Schuurman, Henk-Jan
- Awwad, Michel
- Cooper, David K C
Publication date
January 2003
DOI Publisher
Wiley ISSN
0908-665X Citation count (estimate)
13Abstract
Natural anti-Gal antibodies (NAb) to Gal epitopes play a key role in the rejection of pig cells or organs transplanted into primates. We have investigated the effect on NAb return after extracorporeal immunoadsorption (EIA) of the continuous intravenous (i.v.) infusion of (i) bovine serum albumin conjugated to Gal type 6 oligosaccharides (BSA-Gal) or (ii) a poly l-lysine backbone conjugated to Gal type 2 or 6 oligosaccharides (PLL-Gal)
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