A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.

Looney, M.R.
Sartori, C.
Chakraborty, S.
James, P.F.
Lingrel, J.B.
Matthay, M.A.

January 2005

Impaired epithelial sodium channel function predisposes to delayed resorption of pulmonary edema and...

ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1.

Planès, C.
Randrianarison, N.H.
Charles, R.P.
Frateschi, S.
Cluzeaud, F.
Vuagniaux, G.
Soler, P.
Clerici, C.
Rossier, B.C.
Hummler, E.

January 2010

Sodium transport via epithelial sodium channels (ENaC) expressed in alveolar epithelial cells (AEC) ...

Structure function relationships of ENaC and its role in sodium handling.

Schild, L.
Kellenberger, S.

January 2001

The epithelial sodium channel (ENaC) in the apical membrane of polarized epithelial cells is the rat...

A novel tumor necrosis factor–mediated mechanism of direct epithelial sodium channel activation

Czikora, István
Alli, Abdel
Bao, Hui-Fang
Kaftan, David
Sridhar, Supriya
Apell, Hans-Jürgen
Gorshkov, Boris
White, Richard
Zimmermann, Astrid
Wendel, Albrecht
Pauly-Evers, Meike
Hamacher, Jürg
Garcia-Gabay, Irène
Fischer, Bernhard
Verin, Alexander
Bagi, Zsolt
Pittet, Jean Francois
Shabbir, Waheed
Lemmens-Gruber, Rosa
Chakraborty, Trinad
Lazrak, Ahmed
Matthay, Michael A.
Eaton, Douglas C.
Lucas, Rudolf

September 2014

Rationale: Alveolar liquid clearance is regulated by Na+ uptake through the apically expressed epith...

Transepithelial sodium and water transport in the lung. Major player and novel therapeutic target in pulmonary edema.

Sartori, C.
Matthay, M.A.
Scherrer, U.

January 2001

Active transepithelial transport of sodium from the airspaces to the lung interstitium is a primary ...

Amiloride-sensitive sodium channels and pulmonary edema

Althaus, Mike
Clauss, Wolfgang G.
Fronius, Martin

December 2010

The development of pulmonary edema can be considered as a combination of alveolar flooding via incre...

Importance of ENaC-mediated sodium transport in alveolar fluid clearance using genetically-engineered mice.

Hummler, E.
Planès, C.

January 2010

The lung possesses specific transport systems that intra- and extracellularly maintain salt and flui...

Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema.

Solymosi, E.A.
Kaestle-Gembardt, S.M.
Vadász, I.
Wang, L.
Neye, N.
Chupin, C.J.
Rozowsky, S.
Ruehl, R.
Tabuchi, A.
Schulz, H.
Kapus, A.
Morty, R.E.
Kuebler, W.M.

January 2013

Alveolar fluid clearance driven by active epithelial Na(+) and secondary Cl(-) absorption counteract...

beta-Liddle mutation of the epithelial sodium channel increases alveolar fluid clearance and reduces the severity of hydrostatic pulmonary oedema in mice

Randrianarison, N.
Escoubet, B.
Ferreira, C.
Fontayne, A.
Fowler-Jaeger, N.
Clerici, C.
Hummler, E.
Rossier, B. C.
Planes, C.

July 2007

Transepithelial sodium transport via alveolar epithelial Na(+) channels and Na(+),K(+)-ATPase consti...

Function of the epithelial sodium channel ENaC in acute lung injury

ROUX, Jérémie
BARBRY, Pascal
PITTET, Jean-François

January 2005

L objectif de cette thèse est de mettre en évidence le rôle des canaux ioniques de l épithélium alvé...

The Role of Sodium-coupled Neutral Amino Acid Transporters in Alveolar Fluid Homeostasis

Rozowsky, Simon Kevin

November 2013

Alveolar fluid clearance (AFC) is a physiological process by which the lungs remove fluid from the a...

Mechanisms involved in sodium uptake activation by the Tumor Necrosis Factor-derived TIP peptide

DULEBO, Alexander

January 2012

The Tumor Necrosis Factor derived-TIP peptide is a small 17 amino acids cyclic peptide with lectin-l...

Alveolar epithelial fluid transport in acute lung injury: new insights.

Sartori, C.
Matthay, M.A.

January 2002

Pulmonary oedema is a life-threatening condition that frequently leads to acute respiratory failure....

TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Peters, D.M.
Vadász, I.
Wujak, L.
Wygrecka, M.
Olschewski, A.
Becker, C.
Herold, S.
Papp, R.
Mayer, K.
Rummel, S.
Brandes, R.P.
Günther, A.
Waldegger, S.
Eickelberg, O.
Seeger, W.
Morty, R.E.

January 2014

GF-β is a pathogenic factor in patients with acute respiratory distress syndrome (ARDS), a cond...

Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha.

Elia, N.
Tapponnier, M.
Matthay, M.A.
Hamacher, J.
Pache, J.C.
Brundler, M.A.
Totsch, M.
De Baetselier, P.
Fransen, L.
Fukuda, N.
Morel, D.R.
Lucas, R.

January 2003

Tumor necrosis factor-alpha (TNF-alpha) activates sodium channels in Type II alveolar epithelial cel...

Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.

Looney, M.R.
Sartori, C.
Chakraborty, S.
James, P.F.
Lingrel, J.B.
Matthay, M.A.

January 2005

Impaired epithelial sodium channel function predisposes to delayed resorption of pulmonary edema and...

ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1.

Planès, C.
Randrianarison, N.H.
Charles, R.P.
Frateschi, S.
Cluzeaud, F.
Vuagniaux, G.
Soler, P.
Clerici, C.
Rossier, B.C.
Hummler, E.

January 2010

Sodium transport via epithelial sodium channels (ENaC) expressed in alveolar epithelial cells (AEC) ...

Structure function relationships of ENaC and its role in sodium handling.

Schild, L.
Kellenberger, S.

January 2001

The epithelial sodium channel (ENaC) in the apical membrane of polarized epithelial cells is the rat...

A novel tumor necrosis factor–mediated mechanism of direct epithelial sodium channel activation

Czikora, István
Alli, Abdel
Bao, Hui-Fang
Kaftan, David
Sridhar, Supriya
Apell, Hans-Jürgen
Gorshkov, Boris
White, Richard
Zimmermann, Astrid
Wendel, Albrecht
Pauly-Evers, Meike
Hamacher, Jürg
Garcia-Gabay, Irène
Fischer, Bernhard
Verin, Alexander
Bagi, Zsolt
Pittet, Jean Francois
Shabbir, Waheed
Lemmens-Gruber, Rosa
Chakraborty, Trinad
Lazrak, Ahmed
Matthay, Michael A.
Eaton, Douglas C.
Lucas, Rudolf

September 2014

Rationale: Alveolar liquid clearance is regulated by Na+ uptake through the apically expressed epith...

Transepithelial sodium and water transport in the lung. Major player and novel therapeutic target in pulmonary edema.

Sartori, C.
Matthay, M.A.
Scherrer, U.

January 2001

Active transepithelial transport of sodium from the airspaces to the lung interstitium is a primary ...

Amiloride-sensitive sodium channels and pulmonary edema

Althaus, Mike
Clauss, Wolfgang G.
Fronius, Martin

December 2010

The development of pulmonary edema can be considered as a combination of alveolar flooding via incre...

Importance of ENaC-mediated sodium transport in alveolar fluid clearance using genetically-engineered mice.

Hummler, E.
Planès, C.

January 2010

The lung possesses specific transport systems that intra- and extracellularly maintain salt and flui...

Chloride transport-driven alveolar fluid secretion is a major contributor to cardiogenic lung edema.

Solymosi, E.A.
Kaestle-Gembardt, S.M.
Vadász, I.
Wang, L.
Neye, N.
Chupin, C.J.
Rozowsky, S.
Ruehl, R.
Tabuchi, A.
Schulz, H.
Kapus, A.
Morty, R.E.
Kuebler, W.M.

January 2013

Alveolar fluid clearance driven by active epithelial Na(+) and secondary Cl(-) absorption counteract...

beta-Liddle mutation of the epithelial sodium channel increases alveolar fluid clearance and reduces the severity of hydrostatic pulmonary oedema in mice

Randrianarison, N.
Escoubet, B.
Ferreira, C.
Fontayne, A.
Fowler-Jaeger, N.
Clerici, C.
Hummler, E.
Rossier, B. C.
Planes, C.

July 2007

Transepithelial sodium transport via alveolar epithelial Na(+) channels and Na(+),K(+)-ATPase consti...

Function of the epithelial sodium channel ENaC in acute lung injury

ROUX, Jérémie
BARBRY, Pascal
PITTET, Jean-François

January 2005

L objectif de cette thèse est de mettre en évidence le rôle des canaux ioniques de l épithélium alvé...

The Role of Sodium-coupled Neutral Amino Acid Transporters in Alveolar Fluid Homeostasis

Rozowsky, Simon Kevin

November 2013

Alveolar fluid clearance (AFC) is a physiological process by which the lungs remove fluid from the a...

Mechanisms involved in sodium uptake activation by the Tumor Necrosis Factor-derived TIP peptide

DULEBO, Alexander

January 2012

The Tumor Necrosis Factor derived-TIP peptide is a small 17 amino acids cyclic peptide with lectin-l...

Alveolar epithelial fluid transport in acute lung injury: new insights.

Sartori, C.
Matthay, M.A.

January 2002

Pulmonary oedema is a life-threatening condition that frequently leads to acute respiratory failure....

TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Peters, D.M.
Vadász, I.
Wujak, L.
Wygrecka, M.
Olschewski, A.
Becker, C.
Herold, S.
Papp, R.
Mayer, K.
Rummel, S.
Brandes, R.P.
Günther, A.
Waldegger, S.
Eickelberg, O.
Seeger, W.
Morty, R.E.

January 2014

GF-β is a pathogenic factor in patients with acute respiratory distress syndrome (ARDS), a cond...

Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha.

Elia, N.
Tapponnier, M.
Matthay, M.A.
Hamacher, J.
Pache, J.C.
Brundler, M.A.
Totsch, M.
De Baetselier, P.
Fransen, L.
Fukuda, N.
Morel, D.R.
Lucas, R.

January 2003

Tumor necrosis factor-alpha (TNF-alpha) activates sodium channels in Type II alveolar epithelial cel...

Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.

Looney, M.R.
Sartori, C.
Chakraborty, S.
James, P.F.
Lingrel, J.B.
Matthay, M.A.

January 2005

Impaired epithelial sodium channel function predisposes to delayed resorption of pulmonary edema and...

ENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1.

Planès, C.
Randrianarison, N.H.
Charles, R.P.
Frateschi, S.
Cluzeaud, F.
Vuagniaux, G.
Soler, P.
Clerici, C.
Rossier, B.C.
Hummler, E.

January 2010

Sodium transport via epithelial sodium channels (ENaC) expressed in alveolar epithelial cells (AEC) ...

Structure function relationships of ENaC and its role in sodium handling.

Schild, L.
Kellenberger, S.

January 2001

The epithelial sodium channel (ENaC) in the apical membrane of polarized epithelial cells is the rat...

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

Abstract

Extracted data

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

Abstract

Extracted data

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