Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative Insult in the rat hippocampus

Al-Omar, Fadhel A.
Nagi, Mahmoud N.
Abdulgadir, Mustafa M.
Al Joni, Khalda S.
Al-Majed, Abdulhakeem A.

Open link

Publication date

January 2006

Publisher

Springer

Journal

issn:0364-3190

Abstract

Oxidative stress is believed to contribute to neurodegeneration following ischemic injury. The present study was undertaken to evaluate the possible antioxidant neuroprotective effect of curcumin (Cur) on neuronal death of hippocampal CA1 neurons following transient forebrain ischemia in rat. Treatment of Cur (200 mg/kg/day, i.p.) at three different times (immediately, 3 h and 24 h after ischemia) significantly (P<0.01) reduced neuronal damage 7 days after ischemia. Also, treatment of ischemic rats with Cur decreased the elevated levels of MDA and increased GSH contents, catalase and SOD activities to normal levels. In the in vitro, Cur was as potent as antioxidant (IC50 = 1 μM) as butylated hydroxytoluene. The present study demonstrates th...

Extracted data

We use cookies to provide a better user experience.

Data Protection

Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative Insult in the rat hippocampus

Abstract

Extracted data

Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative Insult in the rat hippocampus

Abstract

Extracted data

Related items

Related items