Leucine-rich repeat-containing proteins are central to host defense in plants and animals. We show that in the mosquito Anopheles gambiae, two such proteins that antagonize malaria parasite infections, LRIM1 and APL1C, circulate in the hemolymph as a high-molecular-weight complex held together by disulfide bridges. The complex interacts with the complement C3-like protein, TEP1, promoting its cleavage or stabilization and its subsequent localization on the surface of midgut-invading Plasmodium berghei parasites, targeting them for destruction. LRIM1 and APL1C are members of a protein family with orthologs in other disease vector mosquitoes and appear to be important effectors in innate mosquito defenses against human pathogens
Genetically controlled resistance of Anopheles gambiae mosquitoes to Plasmodium falciparum is a comm...
<p>Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pat...
International audienceGenetically controlled resistance of Anopheles gambiae mosquitoes to Plasmodiu...
A novel mosquito-specific family of leucine-rich repeat immune proteins (LRIMs) was recently identif...
SummaryPlasmodium development within Anopheles mosquitoes is a vulnerable step in the parasite trans...
Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pathoge...
The complement-like pathway of the African malaria mosquito Anopheles gambiae provides protection ag...
Anopheles mosquito is a vector of Plasmodium parasite, the causative agent of malaria. The Anopheles...
Natural infection of Anopheles gambiae by malaria-causing Plasmodium parasites is significantly infl...
ABSTRACT Malaria parasite ookinetes must traverse the vector mosquito midgut epithelium to transform...
<div><p>Natural infection of <i>Anopheles gambiae</i> by malaria-causing <i>Plasmodium</i> parasites...
The complement-like pathway of the African malaria mosquito Anopheles gambiae provides protection ag...
<div><p>The complement C3-like protein TEP1 of the mosquito <i>Anopheles gambiae</i> is required for...
Malaria parasites must complete a complex developmental cycle in an Anophelesmosquito vector before ...
Malaria transmission between humans depends on the ability of Anopheles mosquitoes to support Plasmo...
Genetically controlled resistance of Anopheles gambiae mosquitoes to Plasmodium falciparum is a comm...
<p>Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pat...
International audienceGenetically controlled resistance of Anopheles gambiae mosquitoes to Plasmodiu...
A novel mosquito-specific family of leucine-rich repeat immune proteins (LRIMs) was recently identif...
SummaryPlasmodium development within Anopheles mosquitoes is a vulnerable step in the parasite trans...
Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pathoge...
The complement-like pathway of the African malaria mosquito Anopheles gambiae provides protection ag...
Anopheles mosquito is a vector of Plasmodium parasite, the causative agent of malaria. The Anopheles...
Natural infection of Anopheles gambiae by malaria-causing Plasmodium parasites is significantly infl...
ABSTRACT Malaria parasite ookinetes must traverse the vector mosquito midgut epithelium to transform...
<div><p>Natural infection of <i>Anopheles gambiae</i> by malaria-causing <i>Plasmodium</i> parasites...
The complement-like pathway of the African malaria mosquito Anopheles gambiae provides protection ag...
<div><p>The complement C3-like protein TEP1 of the mosquito <i>Anopheles gambiae</i> is required for...
Malaria parasites must complete a complex developmental cycle in an Anophelesmosquito vector before ...
Malaria transmission between humans depends on the ability of Anopheles mosquitoes to support Plasmo...
Genetically controlled resistance of Anopheles gambiae mosquitoes to Plasmodium falciparum is a comm...
<p>Mosquitoes have potent innate defense mechanisms that protect them from infection by diverse pat...
International audienceGenetically controlled resistance of Anopheles gambiae mosquitoes to Plasmodiu...