The Ccr4-Not complex interacts with the mRNA export machinery
- Kerr, Shana C
- Azzouz, Nowel
- Fuchs, Stephen M
- Collart, Martine
- Strahl, Brian D
- Corbett, Anita H
- Laribee, R Nicholas
Publication date
January 2011
DOI Publisher
Public Library of Science (PLoS)Abstract
The Ccr4-Not complex is a key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation. Whether this complex also affects aspects of post-transcriptional gene regulation, such as mRNA export, remains largely unexplored. Human Caf1 (hCaf1), a Ccr4-Not complex member, interacts with and regulates the arginine methyltransferase PRMT1, whose targets include RNA binding proteins involved in mRNA export. However, the functional significance of this regulation is poorly understood
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