Dismembered relics of mafic and ultramafic rock in high-grade basement rocks often record pre-collisional stages of deep lithospheric and/or oceanic mafic magmatism in an orogen. A lens of amphibolites and serpentinites, intercalated between the crystalline Simano and Leventina nappes (lower Penninic nappes, Central Alps, Switzerland) was investigated for the protolith age and chemical and isotopic composition. Despite the polyphase high-grade metamorphic overprinting, primary isotopic and chemical relationships are still preserved and are indicative of an origin in an active margin situation. Trace element geochemistry and Nd isotopes of amphibolites argue for the fractionated gabbros as protoliths, which were formed by the partial melting...