Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals: the Swiss HIV Cohort Study
- Fehr, Jan
- Glass, Tracy R
- Louvel, Séverine
- Hamy, François
- Hirsch, Hans H
- von Wyl, Viktor
- Böni, Jürg
- Yerly Ferrillo, Sabine
- Bürgisser, Philippe
- Cavassini, Matthias
- Fux, Christoph A
- Hirschel, Bernard
- Vernazza, Pietro
- Martinetti, Gladys
- Bernasconi, Enos
- Günthard, Huldrych F
- Battegay, Manuel
- Bucher, Heiner C
- Klimkait, Thomas
Publication date
January 2011
DOI Publisher
Springer Science and Business Media LLCAbstract
Replicative phenotypic HIV resistance testing (rPRT) uses recombinant infectious virus to measure viral replication in the presence of antiretroviral drugs. Due to its high sensitivity of detection of viral minorities and its dissecting power for complex viral resistance patterns and mixed virus populations rPRT might help to improve HIV resistance diagnostics, particularly for patients with multiple drug failures. The aim was to investigate whether the addition of rPRT to genotypic resistance testing (GRT) compared to GRT alone is beneficial for obtaining a virological response in heavily pre-treated HIV-infected patients
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