Synthesis of epothilones A and B in solid and solution phase

Nicolaou, K. C.
Winssinger, Nicolas
Pastor, J.
Ninkovic, S.
Sarabia, F.
He, Y.
Vourloumis, D.
Yang, Z.
Li, T.
Giannakakou, P.
Hamel, E.

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Publication date

January 1997

DOI

10.1038/387268a0

Publisher

Springer Science and Business Media LLC

ISSN

0028-0836

Citation count (estimate)

294

Abstract

Epothilones A and B, two compounds that have been recently isolated from myxobacterium Sorangium cellulosum strain 90, have generated intense interest among chemists, biologists and clinicians owing to the structural complexity, unusual mechanism of interaction with microtubules and anticancer potential of these molecules

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Synthesis of epothilones A and B in solid and solution phase

Abstract

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Synthesis of epothilones A and B in solid and solution phase

Abstract

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