Increase of [(18)F]FLT tumor uptake in vivo mediated by FdUrd: toward improving cell proliferation positron emission tomography
- Viertl, David
- Bischof Delaloye, Angelika
- Lanz, Bernard
- Poitry-Yamate, Carole
- Gruetter, Rolf
- Mlynarik, Vladimir
- Ametamey, Simon M
- Ross, Tobias L
- Lehr, Hans-Anton
- Andre, Pierre-Alain
- Perillo-Adamer, Florence
- Kosinski, Marek
- Dupertuis, Yves Marc
- Buchegger, Franz
Publication date
January 2011
DOI Publisher
Springer Science and Business Media LLCAbstract
3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT), a cell proliferation positron emission tomography (PET) tracer, has been shown in numerous tumors to be more specific than 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) but less sensitive. We studied the capacity of a nontoxic concentration of 5-fluoro-2'-deoxyuridine (FdUrd), a thymidine synthesis inhibitor, to increase uptake of [(18)F]FLT in tumor xenografts
Add to ORKG