Failure to detect xenotropic murine leukemia virus-related virus in blood of individuals at high risk of blood-borne viral infections
- Barnes, Eleanor
- Flanagan, Peter
- Brown, Anthony
- Robinson, Nicola
- Brown, Helen
- McClure, Myra
- Oxenius, Annette
- Collier, Jane
- Weber, Jonathan
- Gunthard, Huldrych F.
- Hirschel, Bernard
- Fidler, Sarah
- Phillips, Rodney
- Frater, John
DOIAbstract
A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe
Add to ORKG