We investigated a possible role of the central glucagon-like peptide (GLP-1) receptor system as an essential brain circuit regulating adiposity through effects on nutrient partitioning and lipid metabolism independent from feeding behavior. Both lean and diet-induced obesity mice were used for our experiments. GLP-1 (7-36) amide was infused in the brain for 2 or 7 d. The expression of key enzymes involved in lipid metabolism was measured by real-time PCR or Western blot. To test the hypothesis that the sympathetic nervous system may be responsible for informing adipocytes about changes in CNS GLP-1 tone, we have performed direct recording of sympathetic nerve activity combined with experiments in genetically manipulated mice lacking beta-ad...
International audienceGlucagon-like peptide-1 (GLP-1) is a peptide released by the intestine and the...
With the high prevalence of overweight and obese people in the United States, understanding the endo...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and glucagon-like pe...
Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonism, used in the treatment of type 2 diabetes,...
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and glucagon-like pe...
The rising prevalence of obesity poses a significant public health challenge, with profound implicat...
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and glucagon-like pe...
The complexity of neural circuits that control food intake and energy balance in the hypothalamic nu...
Obesity is a growing disorder in the United States, affecting over 60% of the population. We previou...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
International audienceGlucagon-like peptide-1 (GLP-1) is a peptide released by the intestine and the...
Obesity is a growing disorder in the United States, affecting over 60% of the population. We previou...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
With the high prevalence of overweight and obese people in the United States, understanding the endo...
International audienceGlucagon-like peptide-1 (GLP-1) is a peptide released by the intestine and the...
With the high prevalence of overweight and obese people in the United States, understanding the endo...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and glucagon-like pe...
Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonism, used in the treatment of type 2 diabetes,...
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and glucagon-like pe...
The rising prevalence of obesity poses a significant public health challenge, with profound implicat...
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and glucagon-like pe...
The complexity of neural circuits that control food intake and energy balance in the hypothalamic nu...
Obesity is a growing disorder in the United States, affecting over 60% of the population. We previou...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
International audienceGlucagon-like peptide-1 (GLP-1) is a peptide released by the intestine and the...
Obesity is a growing disorder in the United States, affecting over 60% of the population. We previou...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...
With the high prevalence of overweight and obese people in the United States, understanding the endo...
International audienceGlucagon-like peptide-1 (GLP-1) is a peptide released by the intestine and the...
With the high prevalence of overweight and obese people in the United States, understanding the endo...
The peptides encoded by the VGF gene are gaining biomedical interest and are increasingly being scru...