Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells
- Attanasio, Catia
- Reymond, Alexandre
- Humbert, Richard
- Lyle, Robert
- Kuehn, Michael S.
- Neph, Shane
- Sabo, Peter J.
- Goldy, Jeff
- Weaver, Molly
- Haydock, Andrew
- Lee, Kristin
- Dorschner, Michael
- Dermitzakis, Emmanouil
- Antonarakis, Stylianos
- Stamatoyannopoulos, John A.
DOIAbstract
BACKGROUND: Conserved non-coding sequences in the human genome are approximately tenfold more abundant than known genes, and have been hypothesized to mark the locations of cis-regulatory elements. However, the global contribution of conserved non-coding sequences to the transcriptional regulation of human genes is currently unknown. Deeply conserved elements shared between humans and teleost fish predominantly flank genes active during morphogenesis and are enriched for positive transcriptional regulatory elements. However, such deeply conserved elements account for <1% of the conserved non-coding sequences in the human genome, which are predominantly mammalian. RESULTS: We explored the regulatory potential of a large sample of these 'comm...
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