The control of glucose metabolism by pancreatic endocrine cells throughout life relies on a tight regulation of the mass of insulin-producing beta-cells. How this homoeostasis is achieved is not well understood. Over the last few years, experimental rodent models with altered beta-cell mass, and, more recently, new transgenic approaches designed to tackle this problem, have provided abundant information. Processes such as beta-cell proliferation and apoptosis, or even beta-cell differentiation from poorly characterized progenitor cells, whether immature or differentiated, appear to be implicated. A complex picture is thus emerging in which the nature of the pancreatic lesion appears to determine the kind of regenerative response. The enviro...
Expansion of pancreatic beta cells in vivo or ex vivo, or generation of beta cells by differentiatio...
Pancreatic islets consist of 60-80% beta cells, which secrete insulin, a hormone of profound importa...
Due to the increasing prevalence of type 1 diabetes and the complications arising from actual therap...
The control of glucose metabolism by pancreatic endocrine cells throughout life relies on a tight re...
The control of glucose metabolism by pancreatic endocrine cells throughout life relies on a tight re...
The lack or dysfunction of insulin-producing beta-cells is the cause of all forms of diabetes. In vi...
The pancreas is composed of two compartments that deliver digestive enzymes and endocrine hormones t...
In all forms of diabetes, β cell mass or function is reduced and therefore the capacity of the pancr...
The pancreas is composed of two main compartments consisting of endocrine and exocrine tissues. The ...
To unravel the cellular and molecular mechanisms involved in beta-cell renewal and expansion through...
In all forms of diabetes, β cell mass or function is reduced and therefore the capacity of the pancr...
BACKGROUND: Pancreatic beta-cells proliferate following administration of the beta-cell toxin strept...
Several studies have shown that the adult pancreas possesses a limited potential for beta-cell regen...
Expansion of pancreatic beta cells in vivo or ex vivo, or generation of beta cells by differentiatio...
Pancreatic islets consist of 60-80% beta cells, which secrete insulin, a hormone of profound importa...
Expansion of pancreatic beta cells in vivo or ex vivo, or generation of beta cells by differentiatio...
Pancreatic islets consist of 60-80% beta cells, which secrete insulin, a hormone of profound importa...
Due to the increasing prevalence of type 1 diabetes and the complications arising from actual therap...
The control of glucose metabolism by pancreatic endocrine cells throughout life relies on a tight re...
The control of glucose metabolism by pancreatic endocrine cells throughout life relies on a tight re...
The lack or dysfunction of insulin-producing beta-cells is the cause of all forms of diabetes. In vi...
The pancreas is composed of two compartments that deliver digestive enzymes and endocrine hormones t...
In all forms of diabetes, β cell mass or function is reduced and therefore the capacity of the pancr...
The pancreas is composed of two main compartments consisting of endocrine and exocrine tissues. The ...
To unravel the cellular and molecular mechanisms involved in beta-cell renewal and expansion through...
In all forms of diabetes, β cell mass or function is reduced and therefore the capacity of the pancr...
BACKGROUND: Pancreatic beta-cells proliferate following administration of the beta-cell toxin strept...
Several studies have shown that the adult pancreas possesses a limited potential for beta-cell regen...
Expansion of pancreatic beta cells in vivo or ex vivo, or generation of beta cells by differentiatio...
Pancreatic islets consist of 60-80% beta cells, which secrete insulin, a hormone of profound importa...
Expansion of pancreatic beta cells in vivo or ex vivo, or generation of beta cells by differentiatio...
Pancreatic islets consist of 60-80% beta cells, which secrete insulin, a hormone of profound importa...
Due to the increasing prevalence of type 1 diabetes and the complications arising from actual therap...